Evidence map›Paper›PMID 28635523›Full record

ArticleJournal of neurotrauma2017

Long-Term Paired Associative Stimulation Enhances Motor Output of the Tetraplegic Hand.

Aleksandra Tolmacheva, Sarianna Savolainen, Erika Kirveskari, Pantelis Lioumis, Linda Kuusela, Nina Brandstack, Aarne Ylinen, Jyrki P Mäkelä, Anastasia Shulga

2 registry-linked trialsOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurotrauma, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 38 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 4 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03459885 nacompletednot on this mapstarted 2018, after this paper: background citation

Long-term Paired Associative Stimulation for Rehabilitation of Lower Extremities in Persons With Incomplete Tetraplegia

TypeinterventionalSponsorHelsinki University Central HospitalRan2018 to 2019Enrolled5ConditionsSpinal Cord Injuries, Spinal Cord DiseasesArmsPaired associative stimulation (with eXimia magnetic stimulator and Dantec Keypoint® electroneuromyography device)
NCT04101916 nacompletednot on this mapstarted 2019, after this paper: background citation

Paired Associative Stimulation in Subacute Spinal Cord Injury

TypeinterventionalSponsorHelsinki University Central HospitalRan2019 to 2025Enrolled18ConditionsSpinal Cord Injuries, Spinal Cord DiseasesArmsPaired associative stimulation, Sham paired associative stimulation
3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 4 syntheses or guidelines pooled it, 63 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Safety and recommendations for TMS use in healthy subjects and patient populations, with updates on training, ethical and regulatory issues: Expert Guidelines.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2021
    Guideline
  5. Trial
  6. Paired associative stimulation improves outcomes when applied at the subacute stage after incomplete cervical spinal cord injury.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
    Trial
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Reliability and Validity of Transcranial Magnetic Stimulation-Electroencephalography Biomarkers.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2023
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Aleksandra Tolmacheva1 BioMag Laboratory, HUS Medical Imaging Center, University of Helsinki and Helsinki University Hospital , Helsinki, Finland .
Sarianna Savolainen2 Validia Rehabilitation Center , Helsinki, Finland .
Erika Kirveskari3 Clinical Neurosciences, Clinical Neurophysiology, HUS Medical Imaging Center, University of Helsinki and Helsinki University Hospital , Helsinki, Finland .
Pantelis Lioumis1 BioMag Laboratory, HUS Medical Imaging Center, University of Helsinki and Helsinki University Hospital , Helsinki, Finland .
Linda Kuusela4 Department of Physics, University of Helsinki , Helsinki, Finland .
Nina Brandstack5 Department of Radiology, HUS Medical Imaging Center, University of Helsinki and Helsinki University Hospital , Helsinki, Finland .
Aarne Ylinen6 Clinical Neurosciences, Neurology, University of Helsinki and Helsinki University Hospital , Helsinki, Finland .
Jyrki P Mäkelä1 BioMag Laboratory, HUS Medical Imaging Center, University of Helsinki and Helsinki University Hospital , Helsinki, Finland .
Anastasia Shulga1 BioMag Laboratory, HUS Medical Imaging Center, University of Helsinki and Helsinki University Hospital , Helsinki, Finland .
University of Helsinki · FIHelsinki University Hospital · FIValidia Rehabilitation · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A large proportion of spinal cord injuries (SCI) are incomplete. Even in clinically complete injuries, silent non-functional connections can be present. Therapeutic approaches that can strengthen transmission in weak neural connections to improve motor performance are needed. Our aim was to determine whether long-term delivery of paired associative stimulation (PAS, a combination of transcranial magnetic stimulation [TMS] with peripheral nerve stimulation [PNS]) can enhance motor output in the hands of patients with chronic traumatic tetraplegia, and to compare this technique with long-term PNS. Five patients (4 males; age 38-68, mean 48) with no contraindications to TMS received 4 weeks (16 sessions) of stimulation. PAS was given to one hand and PNS combined with sham TMS to the other hand. Patients were blinded to the treatment. Hands were selected randomly. The patients were evaluated by a physiotherapist blinded to the treatment. The follow-up period was 1 month. Patients were evaluated with Daniels and Worthingham's Muscle Testing (0-5 scale) before the first stimulation session, after the last stimulation session, and 1 month after the last stimulation session. One month after the last stimulation session, the improvement in the PAS-treated hand was 1.02 ± 0.17 points (p < 0.0001, n = 100 muscles from 5 patients). The improvement was significantly higher in PAS-treated than in PNS-treated hands (176 ± 29%, p = 0.046, n = 5 patients). Long-term PAS might be an effective tool for improving motor performance in incomplete chronic SCI patients. Further studies on PAS in larger patient cohorts, with longer stimulation duration and at earlier stages after the injury, are warranted.

Indexed as

AdultAgedElectric Stimulation TherapyEvoked Potentials, MotorFemaleHandHumansMaleMiddle AgedMotor ActivityMotor CortexMuscle, SkeletalMuscle StrengthQuadriplegiaSpinal Cord InjuriesTranscranial Magnetic Stimulationpaired associative stimulationperipheral electrical stimulationplasticityspinal cord injurytranscranial magnetic stimulation

Identifiers

PMID28635523
PMCPMC5610384
OpenAlexW2637139759

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.