ArticleBritish journal of pharmacology2018
Understanding and improving photo-control of ion channels in nociceptors with azobenzene photo-switches.
Article in British journal of pharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 38 citations in OpenAlex.
- Structure-Property Relationships in Novel Series of Photoswitchable Local Anesthetic Ethercaine Derivatives: Emphasis on Biological and Photophysical Properties.International journal of molecular sciences · 2025Article
- Advances in the Synthesis of Biologically Active Quaternary Ammonium Compounds.International journal of molecular sciences · 2024Review
- Light-Sensitive Open Channel Block of Ionotropic Glutamate Receptors by Quaternary Ammonium Azobenzene Derivatives.International journal of molecular sciences · 2023Article
- Photopharmacology of Ion Channels through the Light of the Computational Microscope.International journal of molecular sciences · 2021Review
- Photoresponsive Amide-Based Derivatives of Azobenzene-4,4'-Dicarboxylic Acid-Experimental and Theoretical Studies.Materials (Basel, Switzerland) · 2021Article
- Optical Assessment of Nociceptive TRP Channel Function at the Peripheral Nerve Terminal.International journal of molecular sciences · 2021Review
- Resolvins: Potent Pain Inhibiting Lipid Mediators via Transient Receptor Potential Regulation.Frontiers in cell and developmental biology · 2020Review
- Optical control of neuronal ion channels and receptors.Nature reviews. Neuroscience · 2019Review
- Holographic two-photon activation for synthetic optogenetics.Nature protocols · 2019Article
- Restoring Vision to the Blind with Chemical Photoswitches.Chemical reviews · 2018Review
- Recent advances in targeting ion channels to treat chronic pain.British journal of pharmacology · 2018Article
- Understanding and improving photo-control of ion channels in nociceptors with azobenzene photo-switches.British journal of pharmacology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
background and purposeThe photo-isomerizable local anaesthetic, quaternary ammonium-azobenzene-quaternary ammonium (QAQ), provides rapid, optical control over pain signalling without involving genetic modification. In darkness or in green light, trans-QAQ blocks voltage-gated K EXPERIMENTAL APPROACH: Electrophysiology and molecular modelling were used to characterize the binding of cis and trans QAQ to voltage-gated K KEY
resultstrans QAQ was sixfold more potent than cis QAQ, in blocking current through Shaker K CONCLUSIONS AND IMPLICATIONS: Light-switchable local anaesthetics provide a means to non-invasively photo-control pain signalling with high selectivity and fast kinetics. Understanding the mode of action of QAQ and related compounds will help to design of drugs with improved photo-pharmacological properties. LINKED ARTICLES: This article is part of a themed section on Recent Advances in Targeting Ion Channels to Treat Chronic Pain. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v175.12/issuetoc.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.