SynthesisBirth defects research2017
Prevalence of Orofacial Clefts among Live Births in China: A Systematic Review and Meta-Analysis.
Synthesis in Birth defects research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Perinatal prevalence of birth defects in the Mainland of China, 2000-2021: a systematic review and meta-analysis.World journal of pediatrics : WJP · 2024Pooled it
- Integrated assessment of differentially expressed plasma microRNAs in subtypes of nonsyndromic orofacial clefts.Medicine · 2018Trial
- Epigenetic Mechanisms in Cleft Lip and Palate: A Comprehensive Review of Current Insights and Future Perspectives.Plastic and reconstructive surgery. Global open · 2026Article
- Review
- Advancements in Pathogenic Genes and Biomarkers for Non-syndromic Cleft Lip With or Without Cleft Palate Via Multiomics.International dental journal · 2026Review
- Artificial intelligence applications in the diagnosis and management of cleft lip and palate: An updated review.Journal of dental sciences · 2026Review
- Prenatal genetic findings using karyotyping and chromosomal microarray analysis in the first-occurrence typical orofacial clefts.Molecular biology reports · 2025Article
- A Single-cell Atlas of Developing Mouse Palates Reveals Cellular and Molecular Transitions in Periderm Cell Fate.Genomics, proteomics & bioinformatics · 2025Article
- Global, regional, and national burden of orofacial clefts, 1990-2021: an analysis of data from the global burden of disease study 2021.Frontiers in medicine · 2025Article
- Orofacial clefts in newborns in Brazil: a time series study, 2010-2021.Epidemiologia e servicos de saude : revista do Sistema Unico de Saude do Brasil · 2025Article
- Burden of orofacial clefts from 1990-2021 at global, regional, and national levels.Frontiers in pediatrics · 2025Article
- The influential factors of depression among caregivers of children with Cleft Lip and/or Palate: a path analysis based on diathesis-stress theoretical model.BMC psychiatry · 2024Article
- [Single nucleotide polymorphism heritability of non-syndromic cleft lip with or without cleft palate in Chinese population].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2024Article
- Case report and functional verification of a novel mutation in the interferon regulatory transcription factor 6 gene in a family with orofacial clefts.American journal of translational research · 2024Article
- Evidence Mapping and Quality Analysis of Systematic Reviews on Various Aspects Related to Cleft Lip and Palate.Journal of clinical medicine · 2023Review
- Incidence of cleft lip and palate, and epidemiology of perinatal deaths related to cleft lip and palate in Hunan Province, China, 2016-2020.Scientific reports · 2023Article
- Histologic Aspect of the Curved Vomerine Mucosa in Cleft Lip and Palate.The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association · 2022Article
- Maternal periconceptional folic acid supplementation reduced risks of non-syndromic oral clefts in offspring.Scientific reports · 2021Article
- [Exploring parent-of-origin effects for non-syndromic cleft lip with or without cleft palate onBeijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2020Article
- [Evaluating the effect of WNT pathway genes considering interactions on the risk of non-syndromic oral clefts among Chinese populations].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundOrofacial clefts (OFCs) are common human birth defects in China. However, studies on the prevalence of OFCs present inconsistent results. The overall prevalence and geographic distribution of OFCs are poorly described in China. Thus, we conducted a systematic review and meta-analysis to estimate the prevalence of OFCs.
methodsThe systematic review and meta-analysis were conducted on the basis of an established protocol (PROSPERO 2015: CRD42015030198). We systematically searched for articles in four electronic databases, including Embase, PubMed, Wanfang Database, and China National Knowledge Infrastructure (CNKI) to identify relevant studies about prevalence of OFCs in China. Meta-analysis, including subgroup analysis, was conducted to estimate the pooled prevalence.
resultsA total of 41 studies published between 1986 and 2015 were included in our analysis. The sample size ranged from 2,586 to 4,611,808 live births. The random-effects model of meta-analysis showed that the overall prevalence of OFCs in China was 1.4 per 1000 live births (95% confidence interval [CI], 1.1-1.7). In subgroup analysis based on geographic regions, we found that OFC prevalence in Southwest (2.3 per 1000 live births, 95% CI, 1.1-4.7) was higher than that in other regions of China. There were no significant time trends of OFCs during the study period (p-value = 0.47).
conclusionThe overall prevalence of OFCs in China was 1.4 per 1000 live births. No significant secular trend of prevalence has been found in this analysis. Further studies need to be conducted to explore the etiology of OFC to better control the risk of this common birth defect. Birth Defects Research 109:1011-1019, 2017. © 2017 Wiley Periodicals, Inc.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.