Evidence map›Paper›PMID 28635072›Full record

ArticleAmerican journal of reproductive immunology (New York, N.Y. : 1989)2017

PlGF enhances TLR-dependent inflammatory responses in human mononuclear phagocytes.

Laura F Newell, Shernan G Holtan, Jane E Yates, Leonardo Pereira, Jeffrey W Tyner, Irina Burd, Grover C Bagby

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of reproductive immunology (New York, N.Y. : 1989), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. PlGF Immunological Impact during Pregnancy.International journal of molecular sciences · 2020
    Review
  7. Article
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Laura F NewellHematology and Medical Oncology, Oregon Health & Science University, Knight Cancer Institute, Portland, OR, USA.
Shernan G HoltanDivision of Hematology, Oncology and Transplant, University of Minnesota, Minneapolis, MN, USA.
Jane E YatesNorthwest Veterans Affairs Cancer Research Center, Portland, OR, USA.
Leonardo PereiraDivision of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, OR, USA.
Jeffrey W TynerHematology and Medical Oncology, Oregon Health & Science University, Knight Cancer Institute, Portland, OR, USA.
Irina BurdDepartment of Gynecology and Obstetrics, Integrated Research Center for Fetal Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Grover C BagbyHematology and Medical Oncology, Oregon Health & Science University, Knight Cancer Institute, Portland, OR, USA.
Oregon Health & Science University · USCancer Research Center · USJohns Hopkins Medicine · USUniversity of Minnesota · US

Funding

Scholars in Women's Health Research Across the LifespanK12HD043488 · NICHD · OREGON HEALTH & SCIENCE UNIVERSITY · PI MYATT, LESLIE · 2002 to 2023
$10.4M
NICHD NIH HHS K12 HD043488
6 · The paper itself

Abstract

problemLevels of placental growth factor (PlGF) peak during third trimester of pregnancy, a time when women are at increased risk of virus-induced morbidity. We hypothesized PlGF might contribute to an exaggerated inflammatory response to Toll-like receptor (TLR) activation. METHOD OF STUDY: Primary human adult and cord blood CD14

resultsPlGF significantly enhanced the magnitude and duration of TNF messenger RNA and protein production by TLR-7/8-activated monocytes, and increased subsequent production of TNF-independent inflammatory cytokines. This PlGF/TLR effect involved multiple inflammatory cytokines/chemokines and was seen with the majority of TLR agonists. PlGF enhanced phosphorylation of IkappaB kinase (IKK) in monocytes stimulated with the TLR-7/8 agonist R848, and IKK inhibition completely suppressed the PlGF effect.

conclusionPlGF enhances TLR-signaling upstream of IKK and contributes to an exaggerated pathologic pro-inflammatory state in response to activation of maternal and fetal mononuclear phagocytes by specific TLR agonists.

Indexed as

Cells, CulturedFemaleFetal BloodHumansI-kappa B KinaseImidazolesImmunity, InnateInflammationLeukocytes, MononuclearLipopolysaccharide ReceptorsMembrane ProteinsPregnancyPregnancy Complications, InfectiousPregnancy Trimester, ThirdSignal TransductionToll-Like Receptor 7I-kappa B KinaseImidazolesLipopolysaccharide ReceptorsMembrane ProteinsPIGF protein, humanresiquimodTLR7 protein, humanTLR8 protein, humanToll-Like Receptor 7Toll-Like Receptor 8Tumor Necrosis Factor-alphainnate immunitymononuclear phagocytesplacental growth factorpregnancytoll-like receptorsviral infections

Identifiers

PMID28635072
PMCPMC5915625
OpenAlexW2663712586

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.