ArticleBirth defects research2017
Assisted Reproductive Technology and Birth Defects: Effects of Subfertility and Multiple Births.
Article in Birth defects research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 2 syntheses or guidelines pooled it, 72 citations in OpenAlex.
- Congenital anomalies observed in children conceived through assisted reproductive technology-a systematic review and meta-analysis.Journal of assisted reproduction and genetics · 2025Pooled it
- Evaluation of the Risk of Birth Defects Related to the Use of Assisted Reproductive Technology: An Updated Systematic Review.International journal of environmental research and public health · 2022Pooled it
- Increased risk of congenital anomalies after fertility treatment is partially mediated by multiple birth: a population-based cohort study.Human reproduction (Oxford, England) · 2026Article
- Effects of assisted reproductive techniques on offspring cardiovascular health: a systematic review and meta-analysis.Journal of assisted reproduction and genetics · 2026Review
- In Vitro Fertilization and VACTERL Birth Defects.JAMA network open · 2026Article
- Glycerol Kinase 2 as a Metabolic Sentinel for Human Sperm Motility and Male Fertility.Biomolecules · 2025Review
- Elective single blastocyst transfer can achieve acceptable clinical pregnancy and live birth rates compared with elective double cleavage-stage embryo transfer in fresh cycles.BMC pregnancy and childbirth · 2025Article
- Effects of different embryo culture media on birthweight following assisted reproductive technology.Human reproduction open · 2025Article
- Assisted Reproductive Technology During COVID-19: A Population-Based Study Of Pregnancy Outcomes.Reproductive sciences (Thousand Oaks, Calif.) · 2024Article
- Fetal deaths from birth defects in Hunan Province, China, 2016-2020.Scientific reports · 2024Article
- Advancements in Hypospadias Management: Trends, Techniques, Training, and Patient-Centric Outcomes.Urology research & practice · 2024Article
- Perinatal deaths attributable to congenital heart defects in Hunan Province, China, 2016-2020.PloS one · 2024Article
- Comparative Proteomic and Phospho-proteomic Analysis of Mouse Placentas Generated via In Vivo and In Vitro Fertilization.Reproductive sciences (Thousand Oaks, Calif.) · 2023Article
- Trends in the incidence of major birth defects after assisted reproductive technologies in Lombardy Region, Northern Italy.Journal of assisted reproduction and genetics · 2023Article
- Assisted reproductive technology: Short- and long-term outcomes.Developmental medicine and child neurology · 2023Review
- The use of IVF/ICSI and risk of postpartum hemorrhage: A retrospective cohort study of 153,765 women in China.Frontiers in public health · 2023Article
- Birth prevalence of genital anomalies among males conceived by intracytoplasmic sperm injection cycles: A cross-sectional study.International journal of reproductive biomedicine · 2023Article
- The risks of birth defects and childhood cancer with conception by assisted reproductive technology.Human reproduction (Oxford, England) · 2022Article
- Article
- Association between perinatal factors and hypospadias in newborns: a retrospective case-control study of 42,244 male infants.BMC pregnancy and childbirth · 2022Article
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 1 country.
Funding
Abstract
backgroundAssisted reproductive technology (ART) has been associated with birth defects, but the contributions of multiple births and underlying subfertility remain unclear. We evaluated the effects of subfertility and mediation by multiple births on associations between ART and nonchromosomal birth defects.
methodsWe identified a retrospective cohort of Massachusetts live births and stillbirths from 2004 to 2010 among ART-exposed, ART-unexposed subfertile, and fertile mothers using linked information from fertility clinics, vital records, hospital discharges, and birth defects surveillance. Log-binomial regression was used to estimate prevalence ratios and 95% confidence intervals (CIs). Mediation analyses were performed to deconstruct the ART-birth defects association into the direct effect of ART, the indirect effect of multiple births, and the effect of ART-multiples interaction.
resultsOf 17,829 ART-exposed births, 355 had a birth defect, compared with 162 of 9431 births to subfertile mothers and 6183 of 445,080 births to fertile mothers. The adjusted prevalence ratio was 1.5 (95% CI, 1.3-1.6) for ART and 1.3 (95% CI, 1.1-1.5) in subfertile compared with fertile deliveries. We observed elevated rates of several birth defects with ART, including tetralogy of Fallot and hypospadias. Subfertility and multiple births affect these associations, with multiple births explaining 36% of the relative effect of ART on nonchromosomal birth defects.
conclusionAlthough the risk of birth defects with ART is small, a substantial portion of the relative effect is mediated through multiple births, with subfertility contributing an important role. Future research is needed to determine the impact of newer techniques, such as single embryo transfer, on these risks. Birth Defects Research 109:1144-1153, 2017. © 2017 Wiley Periodicals, Inc.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.