Evidence map›Paper›PMID 28634892›Full record

ArticleLung2017

Lung Clearance Index (LCI) is Stable in Most Primary Ciliary Dyskinesia (PCD) Patients Managed in a Specialist Centre: a Pilot Study.

S Irving, S Carr, C Hogg, M Loebinger, A Shoemark, A Bush

Open access · greenAbstract readComparative Study
PubMed Publisher
In one paragraph

Article in Lung, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 14 citations in OpenAlex.

  1. Observational
  2. Chronic airway disease in primary ciliary dyskinesia-spiced with geno-phenotype associations.American journal of medical genetics. Part C, Seminars in medical genetics · 2022
    Review
  3. Article
  4. Motile ciliopathies.Nature reviews. Disease primers · 2020
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

S IrvingRoyal Brompton & Harefield NHS Foundation Trust, Royal Brompton Hospital, Sydney Street, London, SW3 6NP, UK. s.irving@rbht.nhs.uk.ORCID 0000-0003-1861-592X
S CarrRoyal Brompton & Harefield NHS Foundation Trust, Royal Brompton Hospital, Sydney Street, London, SW3 6NP, UK.
C HoggRoyal Brompton & Harefield NHS Foundation Trust, Royal Brompton Hospital, Sydney Street, London, SW3 6NP, UK.
M LoebingerRoyal Brompton & Harefield NHS Foundation Trust, Royal Brompton Hospital, Sydney Street, London, SW3 6NP, UK.
A ShoemarkRoyal Brompton & Harefield NHS Foundation Trust, Royal Brompton Hospital, Sydney Street, London, SW3 6NP, UK.
A BushRoyal Brompton & Harefield NHS Foundation Trust, Royal Brompton Hospital, Sydney Street, London, SW3 6NP, UK.
Royal Brompton & Harefield NHS Foundation Trust · GB

Funding

Medical Research Council G1000758
6 · The paper itself

Abstract

Primary ciliary dyskinesia is a condition in which abnormal cilia structure or function leads to reduced mucociliary clearance and obstructive lung disease. Twenty-nine patients had lung clearance index (LCI) measured in 2009 and we attempted to perform a 5-year follow-up. Only 12 patients could be re-recruited, but in this small group LCI was stable over the 5 years, which confirms previous data showing that spirometry is also stable in these patients over the medium term. The two patients with the highest LCI in 2009 had since died, despite one having relatively preserved spirometry at the time. These data may be used to inform sample size calculations of future studies.

Indexed as

Mucociliary ClearanceOutpatient Clinics, HospitalRespiratory Function TestsForced Expiratory VolumeHumansKartagener SyndromeLungPilot ProjectsPredictive Value of TestsPrognosisSpirometryTime FactorsMultiple breath washoutPaediatricsPrimary ciliary dyskinesiaRare disease

Identifiers

PMID28634892
OpenAlexW2671854575

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.