Evidence map›Paper›PMID 28634689›Full record

ArticleCurrent microbiology2017

Survival, Intestinal Mucosa Adhesion, and Immunomodulatory Potential of Lactobacillus plantarum Strains.

Valentini Santarmaki, Yiannis Kourkoutas, Georgia Zoumpopoulou, Eleni Mavrogonatou, Mikis Kiourtzidis, Nikos Chorianopoulos, Chrysoula Tassou, Effie Tsakalidou, Constantinos Simopoulos, Petros Ypsilantis

Abstract read
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In one paragraph

Article in Current microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.7field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 34 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Valentini SantarmakiLaboratory of Applied Microbiology & Biotechnology, Department of Molecular Biology & Genetics, Democritus University of Thrace, 68100, Alexandroupolis, Greece.
Yiannis KourkoutasLaboratory of Applied Microbiology & Biotechnology, Department of Molecular Biology & Genetics, Democritus University of Thrace, 68100, Alexandroupolis, Greece.
Georgia ZoumpopoulouLaboratory of Dairy Research, Department of Food Science and Human Nutrition, Agricultural University of Athens, 11855, Athens, Greece.
Eleni MavrogonatouLaboratory of Cell Proliferation and Ageing, Institute of Biosciences and Applications, National Centre for Scientific Research Demokritos, 15310, Athens, Greece.
Mikis KiourtzidisLaboratory of Applied Microbiology & Biotechnology, Department of Molecular Biology & Genetics, Democritus University of Thrace, 68100, Alexandroupolis, Greece.
Nikos ChorianopoulosInstitute of Technology of Agricultural Products, Hellenic Agricultural Organization DEMETER, 1 S. Venizelou Str, Lykovrissi, 14123, Athens, Greece.
Chrysoula TassouInstitute of Technology of Agricultural Products, Hellenic Agricultural Organization DEMETER, 1 S. Venizelou Str, Lykovrissi, 14123, Athens, Greece.
Effie TsakalidouLaboratory of Dairy Research, Department of Food Science and Human Nutrition, Agricultural University of Athens, 11855, Athens, Greece.
Constantinos SimopoulosLaboratory of Experimental Surgery and Surgical Research, School of Medicine, Democritus University of Thrace, 68100, Alexandroupolis, Greece.
Petros YpsilantisLaboratory of Experimental Surgery and Surgical Research, School of Medicine, Democritus University of Thrace, 68100, Alexandroupolis, Greece. pipsil@med.duth.gr.
Democritus University of Thrace · GRAgricultural University of Athens · GRNational Centre of Scientific Research "Demokritos" · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Survival during transit through the gastrointestinal track, intestinal mucosa adhesion, and a potential immunomodulatory effect of Lactobacillus plantarum strains 2035 and ACA-DC 2640 were investigated in a rat model. According to microbiological and multiplex PCR analysis, both strains were detected in feces 24 h after either single-dose or daily administration for 7 days. Intestinal mucosa adhesion of L. plantarum 2035 was noted in the large intestine at 24 h after single-dose administration, while it was not detected at 48 h. Daily dosing, prolonged detection of the strain up to 48 h post-administration, and expanded adhesion to the small intestine. Adhesion of L. plantarum ACA-DC 2640 to the intestinal mucosa after single-dose administration was prolonged and more extended compared to L. plantarum 2035. Daily dosing increased both the levels and the rate of positive cultures of the strains compared to those of the single-dose scheme. In addition, both strains increased total IgG while decreased IgM and IgA serum levels. In conclusion, L. plantarum 2035 and L. plantarum ACA-DC 2640 survived transit through the gastrointestinal track, exhibited transient distinct adhesion to the intestinal mucosa and modulated the systemic immune response.

Indexed as

Bacterial AdhesionMicrobial ViabilityAnimalsAntibodies, BacterialFecesImmunoglobulin AImmunoglobulin GImmunoglobulin MImmunologic FactorsIntestinal MucosaIntestine, LargeIntestine, SmallLactiplantibacillus plantarumPolymerase Chain ReactionProbioticsRatsAntibodies, BacterialImmunoglobulin AImmunoglobulin GImmunoglobulin MImmunologic Factors

Identifiers

PMID28634689
OpenAlexW2707903108

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.