Evidence map›Paper›PMID 28634611›Full record

ArticleChemical communications (Cambridge, England)2017

Micro- and nano-patterned conductive graphene-PEG hybrid scaffolds for cardiac tissue engineering.

Alec S T Smith, Hyok Yoo, Hyunjung Yi, Eun Hyun Ahn, Justin H Lee, Guozheng Shao, Ekaterina Nagornyak, Michael A Laflamme, Charles E Murry, Deok-Ho Kim

Abstract read
In one paragraph

Article in Chemical communications (Cambridge, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Advances in cardiac tissue engineering and heart-on-a-chip.Journal of biomedical materials research. Part A · 2024
    Review
  10. Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. New treatment methods for myocardial infarction.Frontiers in cardiovascular medicine · 2023
    Review
  17. Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alec S T SmithDepartment of Bioengineering, University of Washington, Seattle, WA 98195, USA. deokho@uw.edu.
Hyok Yoo
Hyunjung Yi
Eun Hyun Ahn
Justin H Lee
Guozheng Shao
Ekaterina Nagornyak
Michael A Laflamme
Charles E Murry
Deok-Ho Kim

Funding

A NANOPATTERNED MEA-BASED FUNCTIONAL PHENOTYPING ASSAY FOR DRUG-INDUCED CARDIOTOXICITY SCREENINGR01HL135143 · NHLBI · UNIVERSITY OF WASHINGTON · PI KIM, DEOK-HO · 2017 to 2021
$1.9M
Injectable myocardial matrix-grapheme composite hydrogels for functional cardiac tissue engineeringR21EB020132 · NIBIB · UNIVERSITY OF WASHINGTON · PI KIM, DEOK-HO · 2016 to 2017
$435k
NHLBI NIH HHS R01 HL135143NIBIB NIH HHS R21 EB020132
6 · The paper itself

Abstract

A lack of electrical conductivity and structural organization in currently available biomaterial scaffolds limits their utility for generating physiologically representative models of functional cardiac tissue. Here we report on the development of scalable, graphene-functionalized topographies with anisotropic electrical conductivity for engineering the structural and functional phenotypes of macroscopic cardiac tissue constructs. Guided by anisotropic electroconductive and topographic cues, the tissue constructs displayed structural property enhancement in myofibrils and sarcomeres, and exhibited significant increases in the expression of cell-cell coupling and calcium handling proteins, as well as in action potential duration and peak calcium release.

Indexed as

Tissue EngineeringAnisotropyBiocompatible MaterialsCalciumCell ProliferationElectric ConductivityGraphiteHumansMyocytes, CardiacNanostructuresPhenotypePolyethylene GlycolsTissue ScaffoldsBiocompatible MaterialsCalciumGraphitePolyethylene Glycols

Identifiers

PMID28634611
PMCPMC5548490

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.