ArticleAdvances in urology2017
A Study of Patients with Primary Mediastinal Germ Cell Tumors Treated Using Multimodal Therapy.
Article in Advances in urology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- Complete radiological and biochemical remission at 26 months in a young adult with primary mediastinal yolk sac tumor: a case report and literature review on multimodal management.Journal of medical case reports · 2026Review
- Current Trends in the Surgical Management of Yolk Sac Tumors.Current oncology (Toronto, Ont.) · 2024Review
- Primary mediastinal yolk sac tumor: A case report and literature review.Clinical case reports · 2023Article
- Multimodality treatment outcome in patients with primary malignant mediastinal germ cell tumor in adults.Cancer reports (Hoboken, N.J.) · 2021Article
- Choriocarcinoma Presenting as a Pleural Effusion.Cureus · 2020Article
- Incidentally discovered primary mediastinal germ cell tumor.JAAPA : official journal of the American Academy of Physician Assistants · 2020Article
- Primary mediastinal yolk sac tumor: a case report and literature review.International journal of clinical and experimental pathology · 2020Article
- Mediastinal germ cell tumors: cohort of patients with this rare entity.Mediastinum (Hong Kong, China) · 2020Article
- Primary mediastinal choriocarcinoma in a female patient: Case report and review of the literature.Gynecologic oncology reports · 2018Article
- Mediastinal germ cell tumors: new therapeutic insights.Journal of thoracic disease · 2017Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesPrimary mediastinal germ cell tumors (PMGCTs) are rare, which often makes them difficult to treat. Herein, we examined patients with PMGCTs who underwent multimodal treatment.
methodsWe examined 6 patients (median age: 25 years, range: 19-27 years) with PMGCTs who underwent multimodal treatment between April 2001 and March 2015. Three patients had seminomas, 2 patients had yolk sac tumors, and 1 patient had choriocarcinoma. The median observation period was 32.5 months (range: 8-84 months).
resultsThree of the 6 patients received initial operation followed by 3-4 courses of chemotherapy (bleomycin, etoposide, and cisplatin (BEP) or etoposide and cisplatin (EP)). One patient developed multiple lung metastases 17 months after surgery; received salvage chemotherapy with vinblastine, ifosfamide, and cisplatin; and achieved complete remission. The remaining 3 patients received initial BEP and EP chemotherapy. Multiple lung metastases and supraclavicular lymph node metastases were detected in 2 of these patients at the initial diagnosis. The patients underwent resections to remove residual tumor after treatment, and no viable tumor cells were found.
conclusionsReliable diagnosis and immediate multimodal treatments are necessary for patients with PMGCTs. The 6 patients treated in our hospital have never experienced recurrence after the multimodal treatment.
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