ArticleFrontiers in neuroscience2017
Inconsistency in Abnormal Brain Activity across Cohorts of ADHD-200 in Children with Attention Deficit Hyperactivity Disorder.
Article in Frontiers in neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- A resting-state functional magnetic resonance imaging meta-analysis of differences in brain activity between children and adolescents with attention-deficit/hyperactivity disorder using activation likelihood estimation.European child & adolescent psychiatry · 2026Pooled it
- Transcranial magnetic stimulation in attention-deficit/hyperactivity disorder: a systematic review and meta-analysis of cortical excitability and therapeutic efficacy.Frontiers in psychiatry · 2025Pooled it
- Neural Correlates of Virtual Reality Intervention in Children With Attention-Deficit/Hyperactivity Disorder: A Resting-State fMRI Study Based on Percent Amplitude of Fluctuation.Brain and behavior · 2026Article
- Frequency-specific static and dynamic neural activity indices in children with different attention deficit hyperactivity disorder subtypes: a resting-state fMRI study.Frontiers in human neuroscience · 2024Article
- Multimodality neuroimaging in vascular mild cognitive impairment: A narrative review of current evidence.Frontiers in aging neuroscience · 2023Review
- Riemannian Geometry of Functional Connectivity Matrices for Multi-Site Attention-Deficit/Hyperactivity Disorder Data Harmonization.Frontiers in neuroinformatics · 2022Article
- The brain mechanism of awakening dysfunction in children with primary nocturnal enuresis based on PVT-NAc neural pathway: a resting-state fMRI study.Scientific reports · 2021Article
- The norepinephrine transporter gene modulates intrinsic brain activity, visual memory, and visual attention in children with attention-deficit/hyperactivity disorder.Molecular psychiatry · 2021Article
- Frequency-specific alterations of the resting-state BOLD signals in nocturnal enuresis: an fMRI Study.Scientific reports · 2021Article
- Abnormal degree centrality in lifelong premature ejaculation patients: an fMRI study.Brain imaging and behavior · 2021Article
- Reducing Inter-Site Variability for Fluctuation Amplitude Metrics in Multisite Resting State BOLD-fMRI Data.Neuroinformatics · 2021Article
- Echo Time Dependency of Local Activity Metrics of Resting-State Functional MRI.Frontiers in neuroscience · 2021Article
- Polygenic Risk Score-Derived Subcortical Connectivity Mediates Attention-Deficit/Hyperactivity Disorder Diagnosis.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2020Article
- Machine Learning Methods for Diagnosing Autism Spectrum Disorder and Attention- Deficit/Hyperactivity Disorder Using Functional and Structural MRI: A Survey.Frontiers in neuroinformatics · 2020Review
- Higher Sensitivity and Reproducibility of Wavelet-Based Amplitude of Resting-State fMRI.Frontiers in neuroscience · 2020Article
- Data-Driven Discovery of Predictors of Virtual Reality Safety and Sense of Presence for Children With Autism Spectrum Disorder: A Pilot Study.Frontiers in psychiatry · 2020Article
- Assessing Fine-Granularity Structural and Functional Connectivity in Children With Attention Deficit Hyperactivity Disorder.Frontiers in human neuroscience · 2020Article
- Examining overlap and homogeneity in ASD, ADHD, and OCD: a data-driven, diagnosis-agnostic approach.Translational psychiatry · 2019Article
- Abnormal Functional Connectivity in Cognitive Control Network, Default Mode Network, and Visual Attention Network in Internet Addiction: A Resting-State fMRI Study.Frontiers in neurology · 2019Article
- Inconsistency in Abnormal Functional Connectivity Across Datasets of ADHD-200 in Children With Attention Deficit Hyperactivity Disorder.Frontiers in psychiatry · 2019Article
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many papers have shown results from the multi-site dataset of resting-state fMRI (rs-fMRI) in attention deficit hyperactivity disorder (ADHD), a data-sharing project named ADHD-200. However, few studies have illustrated that to what extent the pooled findings were consistent across cohorts. The present study analyzed three voxel-wise whole-brain metrics, i.e., amplitude of low-frequency fluctuation (ALFF), regional homogeneity (ReHo), and degree centrality (DC) based on the pooled dataset as well as individual cohort of ADHD-200. In addition to the conventional frequency band of 0.01-0.08 Hz, sub-frequency bands of 0-0.01, 0.01-0.027, 0.027-0.073, 0.073-0.198, and 0.198-0.25 Hz, were assessed. While the pooled dataset showed abnormal activity in some brain regions, e.g., the bilateral sensorimotor cortices, bilateral cerebellum, and the bilateral lingual gyrus, these results were highly inconsistent across cohorts, even across the three cohorts from the same research center. The standardized effect size was rather small. These findings suggested a high heterogeneity of spontaneous brain activity in ADHD. Future studies based on multi-site large-sample dataset should be performed on pooled data and single cohort data, respectively and the effect size must be shown.
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