ArticleScientific reports2017
Topical Fibronectin Improves Wound Healing of Irradiated Skin.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 59 citations in OpenAlex.
- Immunomodulation by collagen VI across fibrotic and tumor microenvironmental contexts.Histology and histopathology · 2026Review
- Hydrogels for Healing Radiation-Injured Tissues and Organs.Gels (Basel, Switzerland) · 2026Review
- Chronic radiation-induced dermatitis: what is new in 2024? A narrative review.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2026Review
- Augmented Wound-Healing Effect of Sodium Thiosulfate-Infused Cosmetic Creams in Frostbite.Pharmaceutics · 2025Article
- Translational Extracellular Matrix Spray-Coating Approach for Large-Scale Bioactive Surface Functionalization and Tissue Repair.Advanced healthcare materials · 2025Article
- Single-cell transcriptional analysis of irradiated skin reveals changes in fibroblast subpopulations and variability in caveolin expression.Radiation oncology (London, England) · 2024Article
- Radiation-induced skin reactions: oxidative damage mechanism and antioxidant protection.Frontiers in cell and developmental biology · 2024Review
- A Thermally Stable Recombinant Human Fibronectin Peptide-Fused Protein (rhFN3C) for Faster Aphthous Ulcer (AU) Healing.Bioengineering (Basel, Switzerland) · 2023Article
- Semi-autonomous wound invasion via matrix-deposited, haptotactic cues.Journal of theoretical biology · 2023Article
- PLCL/PCL Dressings with Platelet Lysate and Growth Factors Embedded in Fibrin for Chronic Wound Regeneration.International journal of nanomedicine · 2023Article
- Characterization of Polyphenolic Compounds fromMolecules (Basel, Switzerland) · 2022Article
- The combination of mesoglycan and VEGF promotes skin wound repair by enhancing the activation of endothelial cells and fibroblasts and their cross-talk.Scientific reports · 2022Article
- Transdermal deferoxamine administration improves excisional wound healing in chronically irradiated murine skin.Journal of translational medicine · 2022Article
- Wound-Healing Potential of Rhoifolin-Rich Fraction Isolated fromPharmaceuticals (Basel, Switzerland) · 2022Article
- Topical α-Gal Nanoparticles Enhance Wound Healing in Radiated Skin.Skin pharmacology and physiology · 2022Article
- Radiation-Induced Tissue Damage: Clinical Consequences and Current Treatment Options.Seminars in plastic surgery · 2021Review
- Adipose-derived stromal cells for nonhealing wounds: Emerging opportunities and challenges.Medicinal research reviews · 2021Review
- Influence of microcurrent on the modulation of remodelling genes in a wound healing assay.Molecular biology reports · 2021Article
- Novel fibrin-fibronectin matrix accelerates mice skin wound healing.Bioactive materials · 2020Article
- The iron-regulated surface determinant B (IsdB) protein fromThe Journal of biological chemistry · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 4 institutions in 1 country.
Funding
Abstract
Wound healing is significantly delayed in irradiated skin. To better understand global changes in protein expression after radiation, we utilized a reverse phase protein array (RPPA) to identify significant changes in paired samples of normal and irradiated human skin. Of the 210 proteins studied, fibronectin was the most significantly and consistently downregulated in radiation-damaged skin. Using a murine model, we confirmed that radiation leads to decreased fibronectin expression in the skin as well as delayed wound healing. Topically applied fibronectin was found to significantly improve wound healing in irradiated skin and was associated with decreased inflammatory infiltrate and increased angiogenesis. Fibronectin treatment may be a useful adjunctive modality in the treatment of non-healing radiation wounds.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.