ArticleEmerging microbes & infections2017
Infections of horses and shrews with Bornaviruses in Upper Austria: a novel endemic area of Borna disease.
Article in Emerging microbes & infections, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28 citing papers in PubMed, 48 citations in OpenAlex.
- Borna Disease Virus 1 as Cause of Fatal Meningoencephalomyelitis in Wild Hedgehogs, Germany, 2022-2025.Emerging infectious diseases · 2026Review
- Spillover infections by rustrela virus, borna disease virus 1 and tick-borne encephalitis virus revealed by retrospective screening of mammalian encephalitis of unknown origin.BMC veterinary research · 2025Article
- Structural insights into the dynamic mechanism of bornavirus polymerase.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Experimental infection of shrews (PNAS nexus · 2025Article
- Lethal Borna disease virus 1 infections of humans and animals - in-depth molecular epidemiology and phylogeography.Nature communications · 2024Article
- Article
- Risk factors for Borna disease virus 1 encephalitis in Germany - a case-control study.Emerging microbes & infections · 2023Article
- Article
- Severe Neurologic Disease in a Horse Caused by Tick-Borne Encephalitis Virus, Austria, 2021.Viruses · 2023Article
- Rustrela Virus-Associated Encephalomyelitis ('Staggering Disease') in Cats from Eastern Austria, 1994-2016.Viruses · 2023Article
- Cencurut virus: A novelOne health (Amsterdam, Netherlands) · 2023Article
- Article
- Human Borna disease virus 1 encephalitis shows marked pro-inflammatory biomarker and tissue immunoactivation during the course of disease.Emerging microbes & infections · 2022Article
- Human Borna disease virus 1 (BoDV-1) encephalitis cases in the north and east of Germany.Emerging microbes & infections · 2022Article
- Avian Bornavirus Research-A Comprehensive Review.Viruses · 2022Review
- Article
- Investigation of fatal human Borna disease virus 1 encephalitis outside the previously known area for human cases, Brandenburg, Germany - a case report.BMC infectious diseases · 2021Article
- Active Case Finding of Current Bornavirus Infections in Human Encephalitis Cases of Unknown Etiology, Germany, 2018-2020.Emerging infectious diseases · 2021Article
- No evidence for European bats serving as reservoir for Borna disease virus 1 or other known mammalian orthobornaviruses.Virology journal · 2020Article
- Infectious Wildlife Diseases in Austria-A Literature Review From 1980 Until 2017.Frontiers in veterinary science · 2020Review
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Borna disease, a lethal infection with Borna disease virus-1 (BoDV-1), was diagnosed in four horses from Upper Austria in 2015 and 2016. All cases occurred in winter (two cases in February 2015 and two cases in December 2016), and the maximal distance of the affected stables was 17 km. To demonstrate whether the causative agent was also harbored by its reservoir host, the bicolored white-toothed shrew (Crocidura leucodon), 28 shrews from this geographic area were collected in 2015 and investigated for the presence of BoDV-1. The shrew species were identified according to taxonomic clues and molecular barcodes. Affected horses and all shrews were investigated using histology, immunohistochemistry (IHC) and reverse transcription PCR. The horses exhibited severe nonpurulent encephalitis. Large amounts of BoDV-1 antigen were identified in their CNS. Among the 28 shrews, nine were identified as C. leucodon and 13 as Sorex araneus (Common shrew; Eurasian shrew). Six C. leucodon (66.7%) and one S. araneus (7.7%) had BoDV-1 infections. In accordance with previous findings, the IHC of C. leucodon exhibited a high amount of viral antigen in many neural and extraneural tissues. By contrast, the single positive S. araneus had an exclusively neural staining pattern. Of all positive samples, whole-genome BoDV-1 sequences were generated. The acquired sequences of the affected shrews were not identical to each other and clustered around the sequences of the diseased horses belonging, surprisingly, to the German 'strain V' cluster.
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