ArticleScientific reports2017
Sirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 28 citations in OpenAlex.
- Article
- Using weight loss to predict outcome and define a humane endpoint in preclinical sepsis studies.Scientific reports · 2024Article
- Dual modifying of MAVS at lysine 7 by SIRT3-catalyzed deacetylation and SIRT5-catalyzed desuccinylation orchestrates antiviral innate immunity.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Sirtuins are crucial regulators of T cell metabolism and functions.Experimental & molecular medicine · 2022Review
- The Effect of PGC-1alpha-SIRT3 Pathway Activation onPathogens (Basel, Switzerland) · 2022Article
- Sirtuin 3 Downregulation inmBio · 2021Article
- NADFrontiers in molecular biosciences · 2021Review
- Sirtuin 5 is Dispensable for CD8Frontiers in cell and developmental biology · 2021Article
- Trained Immunity Confers Prolonged Protection From Listeriosis.Frontiers in immunology · 2021Article
- Sirtuin 3 is essential for host defense againstVirulence · 2020Article
- Sirtuin 3 deficiency does not impede digit regeneration in mice.Scientific reports · 2019Article
- Sirtuin-1 in immunotherapy: A Janus-headed target.Journal of leukocyte biology · 2019Review
- SIRT3 promotes antimycobacterial defenses by coordinating mitochondrial and autophagic functions.Autophagy · 2019Article
- Impact of the Dual Deletion of the Mitochondrial Sirtuins SIRT3 and SIRT5 on Anti-microbial Host Defenses.Frontiers in immunology · 2019Article
- Dual Deletion of the Sirtuins SIRT2 and SIRT3 Impacts on Metabolism and Inflammatory Responses of Macrophages and Protects From Endotoxemia.Frontiers in immunology · 2019Article
- Restoring T Cell Tolerance, Exploring the Potential of Histone Deacetylase Inhibitors for the Treatment of Juvenile Idiopathic Arthritis.Frontiers in immunology · 2019Review
- Regulation of Adaptive Immune Cells by Sirtuins.Frontiers in endocrinology · 2019Review
- Histone deacetylase function in CD4Nature reviews. Immunology · 2018Review
- Sirtuins and Immuno-Metabolism of Sepsis.International journal of molecular sciences · 2018Review
- Sirtuin 5 Deficiency Does Not Compromise Innate Immune Responses to Bacterial Infections.Frontiers in immunology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Sirtuin 3 (SIRT3) is the main mitochondrial deacetylase. SIRT3 regulates cell metabolism and redox homeostasis, and protects from aging and age-associated pathologies. SIRT3 may drive both oncogenic and tumor-suppressive effects. SIRT3 deficiency has been reported to promote chronic inflammation-related disorders, but whether SIRT3 impacts on innate immune responses and host defenses against infections remains essentially unknown. This aspect is of primary importance considering the great interest in developing SIRT3-targeted therapies. Using SIRT3 knockout mice, we show that SIRT3 deficiency does not affect immune cell development and microbial ligand-induced proliferation and cytokine production by splenocytes, macrophages and dendritic cells. Going well along with these observations, SIRT3 deficiency has no major impact on cytokine production, bacterial burden and survival of mice subjected to endotoxemia, Escherichia coli peritonitis, Klebsiella pneumoniae pneumonia, listeriosis and candidiasis of diverse severity. These data suggest that SIRT3 is not critical to fight infections and support the safety of SIRT3-directed therapies based on SIRT3 activators or inhibitors for treating metabolic, oncologic and neurodegenerative diseases without putting patients at risk of infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.