Evidence map›Paper›PMID 28634301›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Microbial glycoside hydrolases as antibiofilm agents with cross-kingdom activity.

Brendan D Snarr, Perrin Baker, Natalie C Bamford, Yukiko Sato, Hong Liu, Mélanie Lehoux, Fabrice N Gravelat, Hanna Ostapska, Shane R Baistrocchi, Robert P Cerone and 5 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 1 pooled it
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 1 synthesis or guideline pooled it, 94 citations in OpenAlex.

  1. BioprospectingFrontiers in fungal biology · 2021
    Pooled it
  2. ImagingmBio · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Biofilm · 2025
    Article
  8. Article
  9. Review
  10. Review
  11. Review
  12. Article
  13. How Three Self-Secreted Biofilm Exopolysaccharides ofInternational journal of molecular sciences · 2023
    Review
  14. Article
  15. Review
  16. Review
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 2 countries.

Brendan D SnarrDepartment of Microbiology and Immunology, McGill University, Montreal, QC, H3A 2B4, Canada.
Perrin BakerProgram in Molecular Medicine, Research Institute, The Hospital for Sick Children, Toronto, ON, M5G 1X8, Canada.
Natalie C BamfordProgram in Molecular Medicine, Research Institute, The Hospital for Sick Children, Toronto, ON, M5G 1X8, Canada.
Yukiko SatoDepartment of Microbiology and Immunology, McGill University, Montreal, QC, H3A 2B4, Canada.
Hong LiuLos Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA 90502.
Mélanie LehouxDepartment of Medicine, Infectious Diseases and Immunity in Global Health Program, Centre for Translational Biology, McGill University Health Centre, Montreal, QC, H4A 3J1, Canada.
Fabrice N GravelatDepartment of Medicine, Infectious Diseases and Immunity in Global Health Program, Centre for Translational Biology, McGill University Health Centre, Montreal, QC, H4A 3J1, Canada.
Hanna OstapskaDepartment of Microbiology and Immunology, McGill University, Montreal, QC, H3A 2B4, Canada.
Shane R BaistrocchiDepartment of Microbiology and Immunology, McGill University, Montreal, QC, H3A 2B4, Canada.
Robert P CeroneDepartment of Microbiology and Immunology, McGill University, Montreal, QC, H3A 2B4, Canada.
Elan E FillerLos Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA 90502.
Matthew R ParsekDepartment of Microbiology, University of Washington, Seattle, WA 98195.
Scott G FillerLos Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA 90502.
P Lynne HowellProgram in Molecular Medicine, Research Institute, The Hospital for Sick Children, Toronto, ON, M5G 1X8, Canada; don.sheppard@mcgill.ca howell@sickkids.ca.
Donald C SheppardDepartment of Microbiology and Immunology, McGill University, Montreal, QC, H3A 2B4, Canada; don.sheppard@mcgill.ca howell@sickkids.ca.
McGill University · CAMcGill University Health Centre · CAHarbor–UCLA Medical Center · USHospital for Sick Children · CAThe Lundquist Institute · USUniversity of Toronto · CAUniversity of Washington · US

Funding

The pel exopolysaccharide gene cluster of Pseudomonas aeruginosaR01AI077628 · NIAID · UNIVERSITY OF WASHINGTON · PI MATTHEW R. PARSEK, Daniel J Wozniak · 2009 to 2026
$7.1M
CIHR 123306CIHR 43998CIHR 81361NIAID NIH HHS R01 AI077628
6 · The paper itself

Abstract

Galactosaminogalactan and Pel are cationic heteropolysaccharides produced by the opportunistic pathogens

Indexed as

BiofilmsA549 CellsAnimalsAntifungal AgentsAnti-Infective AgentsAspergillosisAspergillus fumigatusBacterial ProteinsFemaleGlycoside HydrolasesHumansMiceMice, Inbred BALB CMicrobial Sensitivity TestsPolysaccharidesPseudomonas aeruginosaAntifungal AgentsAnti-Infective AgentsBacterial ProteinsGlycoside HydrolasesPolysaccharidesAspergillusbiofilmexopolysaccharidePseudomonastherapeutics

Identifiers

PMID28634301
PMCPMC5502622
OpenAlexW2698205240

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.