Evidence map›Paper›PMID 28634299›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Biosynthesis of isonitrile lipopeptides by conserved nonribosomal peptide synthetase gene clusters in Actinobacteria.

Nicholas C Harris, Michio Sato, Nicolaus A Herman, Frederick Twigg, Wenlong Cai, Joyce Liu, Xuejun Zhu, Jordan Downey, Ryan Khalaf, Joelle Martin and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 89 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Kupyaphores─Self-Assembling Diisocyanolipopeptide ZnJournal of the American Chemical Society · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Copper-chelating natural products.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2025
    Review
  11. Article
  12. Article
  13. Biosynthesis of isonitrile lipopeptides.Current opinion in chemical biology · 2024
    Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Nicholas C HarrisDepartment of Plant and Microbial Biology, University of California, Berkeley, CA 94720.
Michio SatoDepartment of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422-8526, Japan.
Nicolaus A HermanDepartment of Chemical and Biomolecular Engineering, University of California, Berkeley, CA 94720.
Frederick TwiggDepartment of Chemical and Biomolecular Engineering, University of California, Berkeley, CA 94720.
Wenlong CaiDepartment of Chemical and Biomolecular Engineering, University of California, Berkeley, CA 94720.
Joyce LiuDepartment of Bioengineering, University of California, Berkeley, CA 94720.
Xuejun ZhuDepartment of Chemical and Biomolecular Engineering, University of California, Berkeley, CA 94720.
Jordan DowneyDepartment of Chemical and Biomolecular Engineering, University of California, Berkeley, CA 94720.
Ryan KhalafDepartment of Chemistry, University of California, Berkeley, CA 94720.
Joelle MartinDepartment of Chemistry, University of California, Berkeley, CA 94720.
Hiroyuki KoshinoRIKEN Physical Center for Sustainable Resource Science, Wako, Saitama 3510198, Japan.
Wenjun ZhangDepartment of Chemical and Biomolecular Engineering, University of California, Berkeley, CA 94720; wjzhang@berkeley.edu.ORCID 0000-0001-9348-972X
University of California, Berkeley · USChan Zuckerberg Initiative (United States) · USRIKEN Center for Sustainable Resource Science · JPUniversity of Shizuoka · JP

Funding

In Situ Natural Product Labeling and ApplicationsDP2AT009148 · NCCIH · UNIVERSITY OF CALIFORNIA BERKELEY · PI ZHANG, WENJUN · 2015 to 2020
$2.8M
NCCIH NIH HHS DP2 AT009148
6 · The paper itself

Abstract

A putative lipopeptide biosynthetic gene cluster is conserved in many species of Actinobacteria, including

Indexed as

Multigene FamilyActinobacteriaBiological TransportCatalysisChromatographyChromatography, Ion ExchangeEscherichia coliFatty AcidsGene DeletionLipopeptidesLysineMetalsMutationMycobacterium marinumMycobacterium tuberculosisPeptide SynthasesFatty AcidsLipopeptidesLysineMetalsPeptide Synthasesbiosynthetic enzymesmetal transportmycobacteria

Identifiers

PMID28634299
PMCPMC5502637
OpenAlexW2950436573

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.