ArticleProceedings of the National Academy of Sciences of the United States of America2017
Population-genomic inference of the strength and timing of selection against gene flow.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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Who cites it
62 citing papers in PubMed, 135 citations in OpenAlex.
- The Signal of Admixture Can Decay Rapidly When Using Clustering-Based Methods.Molecular ecology resources · 2026Article
- Introgression and Divergence in a Young Species Group.Molecular ecology · 2026Article
- Evolution of genome-wide barriers to gene flow during complex speciation in rattlesnakes.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Examining the Role of a Chromosomal Inversion in Accumulating Adaptive and Barrier Loci in a Cold-adapted Insect Species.Genome biology and evolution · 2026Article
- Evolution of Hybrid Inviability Associated With Chromosome Fusions.Molecular ecology · 2025Article
- Speciation Genomics in the Tiger Whiptail Lizards (Aspidoscelis tigris Complex).Genome biology and evolution · 2025Article
- Ecotypic divergence in Mongolian Scots pine persists via large-effect genetic adaptation and phenotypic plasticity.BMC plant biology · 2025Article
- Disentangling Complex Histories of Hybridisation: The Genomic Consequences of Ancient and Recent Introgression in Channel Island Monkeyflowers.Molecular ecology · 2025Article
- Recent rapid radiation of apex predators suggests dramatic biodiversity turnover in an ancient lake.bioRxiv : the preprint server for biology · 2025Article
- Adaptive Introgression as an Evolutionary Force: A Meta-Analysis of Knowledge Trends.Evolutionary applications · 2025Article
- Genomic regions of current low hybridisation mark long-term barriers to gene flow in scarce swallowtail butterflies.PLoS genetics · 2025Article
- Population genetic structure of Uroteuthis edulis in the East China Sea based on the COI gene.Molecular biology reports · 2025Article
- Conserved islands of divergence associated with adaptive variation in sockeye salmon are maintained by multiple mechanisms.Molecular ecology · 2024Article
- The genetic architecture of polygenic local adaptation and its role in shaping barriers to gene flow.Genetics · 2024Article
- Genomic landscape of introgression from the ghost lineage in a gobiid fish uncovers the generality of forces shaping hybrid genomes.Molecular ecology · 2024Article
- Swordtail fish hybrids reveal that genome evolution is surprisingly predictable after initial hybridization.PLoS biology · 2024Article
- Comparative population genomics reveals convergent and divergent selection in the apricot-peach-plum-mei complex.Horticulture research · 2024Article
- The temporal and genomic scale of selection following hybridization.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Genome evolution is surprisingly predictable after initial hybridization.bioRxiv : the preprint server for biology · 2023Article
- Ancient hybridization leads to the repeated evolution of red flowers across a monkeyflower radiation.Evolution letters · 2023Article
2 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
The interplay of divergent selection and gene flow is key to understanding how populations adapt to local environments and how new species form. Here, we use DNA polymorphism data and genome-wide variation in recombination rate to jointly infer the strength and timing of selection, as well as the baseline level of gene flow under various demographic scenarios. We model how divergent selection leads to a genome-wide negative correlation between recombination rate and genetic differentiation among populations. Our theory shows that the selection density (i.e., the selection coefficient per base pair) is a key parameter underlying this relationship. We then develop a procedure for parameter estimation that accounts for the confounding effect of background selection. Applying this method to two datasets from
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.