Evidence map›Paper›PMID 28634232›Full record

ArticleThe Journal of biological chemistry2017

The phosphocarrier protein HPr of the bacterial phosphotransferase system globally regulates energy metabolism by directly interacting with multiple enzymes in

Irina A Rodionova, Zhongge Zhang, Jitender Mehla, Norman Goodacre, Mohan Babu, Andrew Emili, Peter Uetz, Milton H Saier

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 46 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Proteomic analysis to unravel the biochemical mechanisms triggered by Bacillus toyonensis SFC 500-1E under chromium(VI) and phenol stress.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2023
    Review
  6. How Bacterial Pathogens Coordinate Appetite with Virulence.Microbiology and molecular biology reviews : MMBR · 2023
    Review
  7. Glucose Transport inMicroorganisms · 2023
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Toxins · 2020
    Article
  15. Article
  16. Xenobiotic Effects of Chlorine Dioxide toFrontiers in microbiology · 2020
    Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Irina A RodionovaFrom the Department of Molecular Biology, Division of Biological Sciences, University of California at San Diego, La Jolla, California 92093-0116.
Zhongge ZhangFrom the Department of Molecular Biology, Division of Biological Sciences, University of California at San Diego, La Jolla, California 92093-0116.
Jitender MehlaCenter for the Study of Biological Complexity, Virginia Commonwealth University, Richmond, Virginia 23284.
Norman GoodacreCenter for the Study of Biological Complexity, Virginia Commonwealth University, Richmond, Virginia 23284.
Mohan BabuDepartment of Biochemistry, Research and Innovation Centre, University of Regina, Regina, Saskatchewan S4S 0A2, Canada.
Andrew EmiliDonnelly Centre, University of Toronto, Toronto, Ontario M5S 3E1, Canada.
Peter UetzCenter for the Study of Biological Complexity, Virginia Commonwealth University, Richmond, Virginia 23284.
Milton H SaierFrom the Department of Molecular Biology, Division of Biological Sciences, University of California at San Diego, La Jolla, California 92093-0116,. Electronic address: msaier@ucsd.edu.
University of California, San Diego · USVirginia Commonwealth University · USUniversity of Regina · CAUniversity of Toronto · CA

Funding

The Transporter Classification Database (TCDB)R01GM077402 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SAIER, MILTON H. · 2006 to 2021
$4.7M
Integrative functional mapping of the Escherichia coli membrane interactomeR01GM109895 · NIGMS · VIRGINIA COMMONWEALTH UNIVERSITY · PI SAIER, MILTON H., UETZ, PETER HANS · 2014 to 2017
$1.1M
CIHR MOP-106449NIGMS NIH HHS R01 GM077402NIGMS NIH HHS R01 GM109895
6 · The paper itself

Abstract

The histidine-phosphorylatable phosphocarrier protein (HPr) is an essential component of the sugar-transporting phosphotransferase system (PTS) in many bacteria. Recent interactome findings suggested that HPr interacts with several carbohydrate-metabolizing enzymes, but whether HPr plays a regulatory role was unclear. Here, we provide evidence that HPr interacts with a large number of proteins in

Indexed as

GlycolysisModels, MolecularAdenylate KinaseAldose-Ketose IsomerasesAllosteric RegulationBacterial ProteinsBinding SitesEnergy MetabolismEnzyme ActivationEscherichia coliEscherichia coli ProteinsHistidineIsoenzymesPhosphoenolpyruvate Sugar Phosphotransferase SystemPhosphofructokinase-2PhosphorylationAdenylate KinaseAldose-Ketose IsomerasesBacterial ProteinsEscherichia coli Proteinsglucosamine-6-phosphate isomeraseHistidineIsoenzymesphosphocarrier protein HPrPhosphoenolpyruvate Sugar Phosphotransferase SystemPhosphofructokinase-2Pyruvate KinaseRecombinant Fusion ProteinsRecombinant Proteinsadenylate kinaseadenylate kinase (ADK)glucosamine 6-phosphate deaminase/isomeraseglycolysisHistidine phosphocarrier proteinphosphofructokinaseprotein-protein interactionpyruvate kinase

Identifiers

PMID28634232
PMCPMC5572926
OpenAlexW2710170885

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.