ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2017
Prolonged darkness reduces liver fibrosis in a mouse model of primary sclerosing cholangitis by miR-200b down-regulation.
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Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
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31citing papers in PubMed, 1 pooled it
5.0field-weighted citation impact, top 4% of its field
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Beneficial effects of melatonin on liver fibrosis: A systematic review of current biological evidence.Journal of cellular physiology · 2022Pooled it
- Molecular Mechanisms of Fibrosis in Cholestatic Liver Diseases and Regenerative Medicine-Based Therapies.Cells · 2024Review
- Melatonin attenuates cholestatic liver injury via inhibition of the inflammatory response.Molecular and cellular biochemistry · 2023Article
- The zhuyu pill relieves rat cholestasis by regulating the mRNA expression of lipid and bile metabolism associated genes.Frontiers in pharmacology · 2023Article
- Endothelin Signaling Mediates Biliary-Endothelial Crosstalk in Primary Sclerosing Cholangitis.Cellular and molecular gastroenterology and hepatology · 2023Article
- Review
- Developmental programming: Impact of prenatal bisphenol-A exposure on liver and muscle transcriptome of female sheep.Toxicology and applied pharmacology · 2022Article
- Melatonin: a pleiotropic hormone as a novel potent therapeutic candidate in arsenic toxicity.Molecular biology reports · 2021Review
- The Role of microRNAs in Cholangiocarcinoma.International journal of molecular sciences · 2021Review
- Mast Cells Promote Nonalcoholic Fatty Liver Disease Phenotypes and Microvesicular Steatosis in Mice Fed a Western Diet.Hepatology (Baltimore, Md.) · 2021Observational
- Molecular Mechanisms of Melatonin-Mediated Cell Protection and Signaling in Health and Disease.Pharmaceutics · 2021Review
- Melatonin Protects Cholangiocytes from Oxidative Stress-Induced Proapoptotic and Proinflammatory Stimuli via miR-132 and miR-34.International journal of molecular sciences · 2020Article
- Biliary damage and liver fibrosis are ameliorated in a novel mouse model lacking l-histidine decarboxylase/histamine signaling.Laboratory investigation; a journal of technical methods and pathology · 2020Article
- Amelioration of Large Bile Duct Damage by Histamine-2 Receptor Vivo-Morpholino Treatment.The American journal of pathology · 2020Article
- Melatonin and circadian rhythms in liver diseases: Functional roles and potential therapies.Journal of pineal research · 2020Review
- Modulation of the Tryptophan Hydroxylase 1/Monoamine Oxidase-A/5-Hydroxytryptamine/5-Hydroxytryptamine Receptor 2A/2B/2C Axis Regulates Biliary Proliferation and Liver Fibrosis During Cholestasis.Hepatology (Baltimore, Md.) · 2020Article
- Review
- Melatonin Inhibits Transforming Growth Factor-β1-Induced Epithelial-Mesenchymal Transition in AML12 Hepatocytes.Biology · 2019Article
- Possible application of melatonin treatment in human diseases of the biliary tract.American journal of physiology. Gastrointestinal and liver physiology · 2019Review
- Protective role of melatonin in early-stage and end-stage liver cirrhosis.Journal of cellular and molecular medicine · 2019Review
Corrections and comments
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Authors and funding
16 authors at 5 institutions in 2 countries.
Nan WuDivision of Gastroenterology, Department of Medicine, Texas A&M University Health Science Center, Temple, Texas, USA.
Fanyin MengDivision of Gastroenterology, Department of Medicine, Texas A&M University Health Science Center, Temple, Texas, USA.
Tianhao ZhouDivision of Gastroenterology, Department of Medicine, Texas A&M University Health Science Center, Temple, Texas, USA.
Yuyan HanDivision of Gastroenterology, Department of Medicine, Texas A&M University Health Science Center, Temple, Texas, USA.
Lindsey KennedyDivision of Gastroenterology, Department of Medicine, Texas A&M University Health Science Center, Temple, Texas, USA.
Julie VenterDivision of Gastroenterology, Department of Medicine, Texas A&M University Health Science Center, Temple, Texas, USA.
Heather FrancisDivision of Gastroenterology, Department of Medicine, Texas A&M University Health Science Center, Temple, Texas, USA.
Sharon DeMorrowDivision of Gastroenterology, Department of Medicine, Texas A&M University Health Science Center, Temple, Texas, USA.
Paolo OnoriDepartment of Anatomical, Histological, and Forensic Medicine and Orthopedic Sciences, La Sapienza, Rome, Italy.
Pietro InvernizziCenter for Autoimmune Liver Diseases, Humanitas Clinical and Research Center, Rozzano, Italy.
Francesca BernuzziCenter for Autoimmune Liver Diseases, Humanitas Clinical and Research Center, Rozzano, Italy.
Romina MancinelliDepartment of Anatomical, Histological, and Forensic Medicine and Orthopedic Sciences, La Sapienza, Rome, Italy.
Eugenio GaudioDepartment of Anatomical, Histological, and Forensic Medicine and Orthopedic Sciences, La Sapienza, Rome, Italy.
Antonio FranchittoEleonora Lorillard Spencer Cenci Foundation, Rome, Italy.
Shannon GlaserDivision of Gastroenterology, Department of Medicine, Texas A&M University Health Science Center, Temple, Texas, USA; sglaser@medicine.tamhsc.edu.
Gianfranco AlpiniDivision of Gastroenterology, Department of Medicine, Texas A&M University Health Science Center, Temple, Texas, USA; galpini@tamu.edu.
Texas A&M University · USSapienza University of Rome · ITBaylor Scott & White Medical Center - Temple · USHumanitas University · ITTemple College · US
Funding
GROWTH REGULATION OF THE INTRAHEPATIC BILIARY TREER01DK054811 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ALPINI, GIANFRANCO D, GLASER, SHANNON STROUD · 2000 to 2021
$3.8MDysregulation of hypothalamic neuropeptides is associated with biliary hyperplasiaR01DK082435 · NIDDK · UNIVERSITY OF TEXAS AT AUSTIN · PI DEMORROW, SHARON · 2010 to 2020
$2.7MThe Paracrine Regulation of Mast Cells During Biliary/Cholangiocyte Repair and DamageR01DK108959 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI FRANCIS, HEATHER L · 2016 to 2024
$2.5MRegulation of Bile Duct Growth in Bile Duct Ligated RatsR01DK062975 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ALPINI, GIANFRANCO D, GLASER, SHANNON STROUD · 2005 to 2014
$1.9MRole of Sensory Neuropeptides in the Regulation of Biliary FunctionR01DK076898 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ALPINI, GIANFRANCO D, GLASER, SHANNON STROUD · 2008 to 2016
$1.8MThe Role of Stem Cell Derived Microvesicles in Cholestatic Liver InjuryR01DK107310 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ALPINI, GIANFRANCO D, GLASER, SHANNON STROUD · 2015 to 2019
$1.7MNeuroendocrine Regulation of Biliary Growth and FibrosisR01DK110035 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ALPINI, GIANFRANCO D, GLASER, SHANNON STROUD · 2017 to 2020
$1.2MRegulation of biliary growth and fibrosis by melatoninR01DK115184 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ALPINI, GIANFRANCO D, GLASER, SHANNON STROUD · 2017 to 2020
$1.2MREGULATION OF CELLULAR SENESCENCE BY NON-CODING RNAS IN ALCOHOLIC LIVER INJURYR21AA025997 · NIAAA · SCOTT AND WHITE MEMORIAL HOSPITAL · PI ALPINI, GIANFRANCO D, MENG, FANYIN · 2017 to 2018
$435kRole of stem cell derived microvesicles in alcoholic liver injuryR21AA025157 · NIAAA · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ALPINI, GIANFRANCO D, MENG, FANYIN · 2017 to 2018
$350kMechanisms of synergistic regulation of biliary inflammation and fibrosisI01BX003031 · VA · RLR VA MEDICAL CENTER · PI FRANCIS, HEATHER L · 2016 to 2023
–The role of hypothalamic neuropeptides on biliary function during cholestasisI01BX002638 · VA · OLIN TEAGUE VETERANS CENTER · PI DEMORROW, SHARON · 2015 to 2018
–BLRD VA I01 BX000574BLRD VA I01 BX001724BLRD VA I01 BX002192BLRD VA I01 BX002638BLRD VA I01 BX003031NIAAA NIH HHS R21 AA025157NIAAA NIH HHS R21 AA025997NIDDK NIH HHS R01 DK054811NIDDK NIH HHS R01 DK062975NIDDK NIH HHS R01 DK076898NIDDK NIH HHS R01 DK082435NIDDK NIH HHS R01 DK107310NIDDK NIH HHS R01 DK108959NIDDK NIH HHS R01 DK110035NIDDK NIH HHS R01 DK115184
Abstract
Melatonin therapy or prolonged exposure to complete darkness reduces biliary hyperplasia and liver fibrosis in bile-duct-ligated (BDL) rats; however, no information exists in primary sclerosing cholangitis (PSC). Thus, we aimed to determine the therapeutic effects of prolonged dark therapy or melatonin administration on hepatic fibrosis in the multidrug resistance gene 2-knockout (Mdr2
Indexed as
DarknessAngiogenesis Inducing AgentsAnimalsCell ProliferationCholangitis, SclerosingDisease Models, AnimalDown-RegulationFibrosisHepatic Stellate CellsLiver CirrhosisMaleMelatoninMice, TransgenicMicroRNAsAngiogenesis Inducing AgentsMelatoninMicroRNAsMirn200 microRNA, mouseangiogenesisbiliary epitheliumcholangiopathycholestasismiRNA
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.