ArticleScience signaling2017
Genetic evidence that β-arrestins are dispensable for the initiation of β
Open access · greenAbstract read
In one paragraph
Article in Science signaling, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 127 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
127citing papers in PubMed, 1 pooled it
9.7field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
127 citing papers in PubMed, 1 synthesis or guideline pooled it, 205 citations in OpenAlex.
- The effect of aspirin on inflammatory response in intracranial aneurysm: a systematic review.Inflammopharmacology · 2025Pooled it
- Mechanisms of XCR1 Membrane Trafficking and Constitutive Endocytosis.Basic & clinical pharmacology & toxicology · 2026Article
- Spatial control of parathyroid hormone receptor-1 signaling dictates ligand-specific biological outcomes.Signal transduction and targeted therapy · 2026Article
- Divergent Roles of mGlu2 and mGlu3 Receptors in Amyloid-β Production and Cognitive Dysfunctions in Alzheimer's Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- β-Adrenergic Signaling Promotes Anti-Tumor Immunity in TP53-mutant Oral Squamous Cell Carcinoma.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Spinal motoneuron excitability is homeostatically regulated through β-adrenergic neuromodulation in wild-type and presymptomatic SOD1 mice.Progress in neurobiology · 2026Article
- Signaling bias of the protease-activated receptor-1 is dictated by distinct GRK5 and β-arrestin-2 determinants.Cell reports · 2026Article
- Mechanism of beta-arrestin 1 mediated Src activation via Src SH3 domain revealed by cryo-electron microscopy.Nature communications · 2026Article
- Beta arrestin 1 is a key regulator of pulmonary vascular tone.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Mast cell-specific CysLT2 receptor signaling inhibits cysteinyl leukotriene-dependent mast cell activation and type 2 allergic lung inflammation.Cell reports · 2026Article
- β-Arrestin 1 Differentially Modulates cAMP and ERK Pathways Downstream of the FSH Receptor.Current issues in molecular biology · 2025Article
- Multi-faceted roles of β-arrestins in G protein-coupled receptor endocytosis.Nature communications · 2025Article
- Article
- The clinical implication of β-arrestins-mediated signaling in memory and cognition.Molecular and cellular biochemistry · 2025Review
- Mechanism of beta-arrestin 1 mediated Src activation via Src SH3 domain revealed by cryo-electron microscopy.bioRxiv : the preprint server for biology · 2025Article
- Arrestins as Possible Drug Targets.Biomolecules & therapeutics · 2025Review
- Recent advances in spying on cell signaling with fluorescent biosensors.Current opinion in cell biology · 2025Review
- Helix-bundle and C-terminal GPCR domains differentially influence GRK-specific functions and β-arrestin-mediated regulation.Nature communications · 2025Article
- Probing spatiotemporally organized GPCR signaling using genetically encoded molecular tools.Experimental & molecular medicine · 2025Review
- Discovery of a functionally selective serotonin receptor (5-HTScience advances · 2025Article
67 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 4 institutions in 4 countries.
Morgan O'HayreOral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20852, USA.ORCID http://orcid.org/0000-0003-0965-7773
Kelsie EichelDepartment of Psychiatry, University of California, San Francisco, San Francisco, CA 94158, USA.
Silvia AvinoOral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20852, USA.
Xuefeng ZhaoOral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20852, USA.ORCID http://orcid.org/0000-0001-6860-7739
Dana J SteffenDepartment of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA.
Xiaodong FengOral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20852, USA.ORCID http://orcid.org/0000-0002-2741-5420
Kouki KawakamiGraduate School of Pharmaceutical Sciences, Tohoku University, Aoba-ku, Sendai, Miyagi 980-8578, Japan.
Junken AokiGraduate School of Pharmaceutical Sciences, Tohoku University, Aoba-ku, Sendai, Miyagi 980-8578, Japan.
Karen MesserDepartment of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA.
Roger SunaharaDepartment of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA.
Asuka InoueGraduate School of Pharmaceutical Sciences, Tohoku University, Aoba-ku, Sendai, Miyagi 980-8578, Japan.
Mark von ZastrowDepartment of Psychiatry, University of California, San Francisco, San Francisco, CA 94158, USA.ORCID http://orcid.org/0000-0003-1375-6926
J Silvio GutkindOral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20852, USA. sgutkind@ucsd.edu.ORCID http://orcid.org/0000-0002-5150-4482
National Institutes of Health · USTohoku University · JPUniversity of California San Diego · USUniversity of California, San Francisco · US
Funding
VIRAL MALIGNANCYP30CA023100 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DIANE M SIMEONE · 1985 to 2026
$124.9MThe Presynaptic Vesicle Cycle for the Slow Acting Neurotransmitter SecretionP01DA010154 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KREITZER, ANATOL, SULZER, DAVID · 1995 to 2016
$14.7MGRADUATE TRAINING IN CELLULAR &MOLECULAR PHARMACOLOGYT32GM007752 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BROWN, JOAN HELLER, HANDEL, TRACY M · 1985 to 2023
$13.5MStructure and dynamics of G protein coupled receptor-G protein complexesR01GM083118 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KOBILKA, BRIAN K, SKINIOTIS, GEORGIOS · 2008 to 2023
$8.3MPROTEINS REGULATING ENDOCYTOSIS OF OPIOID RECEPTORSR01DA012864 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Mark E Von Zastrow · 2000 to 2026
$7.9MMembrane Trafficking of Opioid and Adrenergic ReceptorsR01DA010711 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VONZASTROW, MARK E · 2014 to 2023
$4.6MROLE OF G PROTEINS IN GROWTH CONTROL AND CARCINOGENESISZ01DE000551 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI GUTKIND, J · 1992 to 2008
$3.4MNEUROBEHAVIORAL PHARMACOLOGY OF STIMULANTSR01DA006511 · NIDA · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI CUNNINGHAM, KATHRYN A. · 1990 to 2010
$3.3MIntramural NIH HHS Z01 DE000551NCI NIH HHS P30 CA023100NIDA NIH HHS P01 DA010154NIDA NIH HHS R01 DA006511NIDA NIH HHS R01 DA010711NIDA NIH HHS R01 DA012864NIGMS NIH HHS R01 GM083118NIGMS NIH HHS T32 GM007752
Abstract
The β
Indexed as
Signal TransductionAnimalsbeta-Arrestin 1beta-Arrestin 2EndocytosisExtracellular Signal-Regulated MAP KinasesGTP PhosphohydrolasesHEK293 CellsHumansLigandsMiceMice, KnockoutPhosphorylationProtein BindingReceptors, Adrenergic, beta-2RNA Interferencebeta-Arrestin 1beta-Arrestin 2Extracellular Signal-Regulated MAP KinasesGTP PhosphohydrolasesLigandsReceptors, Adrenergic, beta-2RNA, Small InterferingTranscription Activator-Like Effector Nucleases
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.