ArticleJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2017
Restless Legs Syndrome and Sleep-Wake Disturbances in Pregnancy.
Article in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 67 citations in OpenAlex.
- Prevalence and factors associated with restless legs syndrome among pregnant women in middle-income countries: a systematic review and meta-analysis.Frontiers in medicine · 2023Pooled it
- The prevalence of Restless Legs Syndrome/Willis-ekbom disease (RLS/WED) in the third trimester of pregnancy: a systematic review.BMC neurology · 2020Pooled it
- Is Restless Legs Syndrome Associated with an Increased Risk of Mortality? A Meta-Analysis of Cohort Studies.Tremor and other hyperkinetic movements (New York, N.Y.) · 2019Pooled it
- Restless legs syndrome in pregnancy: Frequency, sleep quality, and questionnaire-defined risk of obstructive sleep apnea syndrome.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Global Prevalence of Restless Legs Syndrome and Its Associated Factors in Pregnant Women: A Systematic Review and Meta-Analysis.Health science reports · 2026Review
- The Effect of Clonazepam on Restless Legs Syndrome in a Pregnant Woman: A Case Report of a Patient with Six Previous Pregnancies Accompanied by This Syndrome.Journal of clinical medicine · 2026Article
- Restless legs syndrome among third-trimester pregnant women attending ANC Clinic in public hospitals in North Wollo Zone, Ethiopia.PloS one · 2026Article
- Correlation of sleep-disordered breathing with anemia and microcytosis in premenopausal females: the Nagahama study.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025Article
- Association between restless legs syndrome and sleep quality in Peruvian medical students.PloS one · 2025Article
- Evaluation of the relationship between restless legs syndrome, mental status, and sleep disorders among Moroccan women during their third trimester of pregnancy.Annals of medicine and surgery (2012) · 2024Article
- Sleep pattern and disorders among pregnant women in Ibadan, Southwest Nigeria.BMC women's health · 2024Article
- Article
- Common sleep disorders in pregnancy: a review.Frontiers in medicine · 2023Review
- Dietary Inflammatory Index and sleep quality and duration among pregnant women with overweight or obesity.Sleep · 2022Article
- Poor quality sleep is associated with greater carotid intima media thickness among otherwise healthy resident doctors.Frontiers in epidemiology · 2022Article
- Idiopathic and secondary restless legs syndrome during pregnancy in Japan: Prevalence, clinical features and delivery-related outcomes.PloS one · 2021Observational
- Associations Between Sleep Disorders and Hypertensive Disorders of Pregnancy and Materno-fetal Consequences.Current hypertension reports · 2020Review
- Characteristics of sleep/wake problems and delivery outcomes among pregnant Japanese women without gestational complications.BMC pregnancy and childbirth · 2020Article
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8 authors at 2 institutions in 1 country.
Funding
Abstract
STUDY
objectivesTo estimate the association of restless legs syndrome (RLS) and its frequency with sleep-wake disturbances in pregnancy.
methodsA cohort of 1,563 women in their third trimester of pregnancy were recruited from prenatal clinics between March 2007 and December 2010. Demographic, pregnancy, and delivery data were extracted from medical records and sleep information was collected with questionnaires. To diagnose RLS, we used standardized criteria of RLS symptoms and frequency that were developed by the International Restless Legs Study Group. Logistic regression models were constructed to investigate the association of RLS and its frequency with sleep-wake disturbances (poor sleep quality, daytime sleepiness, poor daytime function) and delivery outcomes.
resultsOverall 36% of the pregnant women had RLS, and half had moderate to severe symptoms. Compared to women without RLS, those with RLS were more likely to have poor sleep quality (odds ratio [OR] 2.2, 95% confidence interval [CI] 1.7-2.9), poor daytime function (OR 1.9, 95% CI 1.4-2.4), and excessive daytime sleepiness (OR 1.6, 95% CI 1.3-2.0). A dose-response relationship also was evident between RLS frequency and each of the sleep-wake disturbances. There was no evidence for any association between RLS and delivery outcomes.
conclusionsRLS is a significant contributor to poor sleep quality, daytime sleepiness, and poor daytime function, all common and often debilitating conditions in pregnancy. Obstetric health care providers should be aware of these associations and screen women for RLS. COMMENTARY: A commentary on this article appears in this issue on page 857.
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