Evidence map›Paper›PMID 28633644›Full record

ArticleBMC anesthesiology2017

Risk factors for pulmonary complications after hepatic resection: role of intraoperative hemodynamic instability and hepatic ischemia.

Victoria Lepere, Antoine Vanier, Yann Loncar, Louis Lemoine, Jean Christophe Vaillant, Antoine Monsel, Eric Savier, Pierre Coriat, Daniel Eyraud

Abstract read
In one paragraph

Article in BMC anesthesiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Victoria LepereDepartment of Anesthesiology and Reanimation, Assistance Publique-Hôpitaux de Paris (AP-HP), University Hospitals Pitié-Salpêtrière Charles-Foix, 43-87 Boulevard de l'Hôpital, 75013, Paris, France.
Antoine VanierDepartment of Biostatistics, Sorbonne University, UPMC University, Paris 06, Paris, France.
Yann LoncarDepartment of Anesthesiology and Reanimation, Assistance Publique-Hôpitaux de Paris (AP-HP), University Hospitals Pitié-Salpêtrière Charles-Foix, 43-87 Boulevard de l'Hôpital, 75013, Paris, France.
Louis LemoineDepartment of Anesthesiology and Reanimation, Assistance Publique-Hôpitaux de Paris (AP-HP), University Hospitals Pitié-Salpêtrière Charles-Foix, 43-87 Boulevard de l'Hôpital, 75013, Paris, France.
Jean Christophe VaillantDepartment of Digestive, HPB Surgery, and Liver Transplantation University Hospitals Pitié-Salpêtrière Charles-Foix, AP-HP, 43-87 Boulevard de l'Hôpital, 75013, Paris, France.
Antoine MonselDepartment of Anesthesiology and Reanimation, Assistance Publique-Hôpitaux de Paris (AP-HP), University Hospitals Pitié-Salpêtrière Charles-Foix, 43-87 Boulevard de l'Hôpital, 75013, Paris, France.
Eric SavierDepartment of Digestive, HPB Surgery, and Liver Transplantation University Hospitals Pitié-Salpêtrière Charles-Foix, AP-HP, 43-87 Boulevard de l'Hôpital, 75013, Paris, France.
Pierre CoriatDepartment of Anesthesiology and Reanimation, Assistance Publique-Hôpitaux de Paris (AP-HP), University Hospitals Pitié-Salpêtrière Charles-Foix, 43-87 Boulevard de l'Hôpital, 75013, Paris, France.
Daniel EyraudDepartment of Anesthesiology and Reanimation, Assistance Publique-Hôpitaux de Paris (AP-HP), University Hospitals Pitié-Salpêtrière Charles-Foix, 43-87 Boulevard de l'Hôpital, 75013, Paris, France. daniel.eyraud@aphp.fr.ORCID 0000-0001-9503-7129

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPostoperative operative pulmonary complications (PPCs) after hepatic surgery are associated with increased length of hospital stays. Intraoperative blood transfusion, extensive resection and different comorbidities have been identified. Other parameters, like time of hepatic ischemia, have neither been clinically studied, though experimental studies show that hepatic ischemia can provide lung injury. The objective of this study was to determinate the risk factors of postoperative pulmonary complications (PPCs) after hepatic resection within 7 postoperative days.

methodNinety-four patients consecutively who underwent elective hepatectomy between January and December 2013. Demographic data, pathological variables, and preoperative, intraoperative, and postoperative variables had been prospectively collected in a data base. The dependant variables studied were the occurrence of PPCs, defined before analysis of the data.

resultsPPCs occurred in 32 (34%) patients. A multivariate analysis allowed identifying the risk factors for PPCs. On multivariate analysis, preoperative gamma-glutamyltransferase (GGT) elevation OR =5,12 [1,85-15,69] p = 0,002, liver ischemia duration OR = 1,03 [1,01-1,06] p = 0,01 and the intraoperative use of vasopressor OR = 4,40 [1,58-13,36] p = 0,006 were independently associated with PPCs. For every 10 min added in ischemia duration, the OR of the risk of PPCs was estimated to be 1.37 (CI

conclusionThree risk factors for PPCs have been identified in a population undergoing liver resection: preoperative GGT elevation, ischemia duration and the intraoperative use of vasopressor. PPCs after liver surgery could be related to lung injury induced by liver ischemia reperfusion and not solely by direct infectious process. That could explain why factors influencing directly or indirectly liver ischemia were independently associated with PPCs.

Indexed as

Cohort StudiesFemalegamma-GlutamyltransferaseHepatectomyHumansIschemiaLiverLung DiseasesMaleMiddle AgedPostoperative ComplicationsRisk FactorsTime FactorsVasoconstrictor Agentsgamma-GlutamyltransferaseVasoconstrictor AgentsGamma-glutamyltransferase (GGT)HepatectomyHepatic ischemiaIschemia reperfusionLung injuryPulmonary complicationsVasopressors

Identifiers

PMID28633644
PMCPMC5477742

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.