Evidence map›Paper›PMID 28633548›Full record

ArticleDrug delivery2017

Polyquaternium-mediated delivery of morpholino oligonucleotides for exon-skipping in vitro and in mdx mice.

Mingxing Wang, Bo Wu, Sapana N Shah, Peijuan Lu, Qilong Lu

Open access · goldAbstract read
In one paragraph

Article in Drug delivery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. In Vivo Evaluation of Dystrophin Exon Skipping in mdx Mice.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Mingxing Wanga McColl-Lockwood Laboratory for Muscular Dystrophy Research , Cannon Research Center, Carolinas Medical Center , Charlotte , NC , United States.
Bo Wua McColl-Lockwood Laboratory for Muscular Dystrophy Research , Cannon Research Center, Carolinas Medical Center , Charlotte , NC , United States.
Sapana N Shaha McColl-Lockwood Laboratory for Muscular Dystrophy Research , Cannon Research Center, Carolinas Medical Center , Charlotte , NC , United States.
Peijuan Lua McColl-Lockwood Laboratory for Muscular Dystrophy Research , Cannon Research Center, Carolinas Medical Center , Charlotte , NC , United States.
Qilong Lua McColl-Lockwood Laboratory for Muscular Dystrophy Research , Cannon Research Center, Carolinas Medical Center , Charlotte , NC , United States.
Carolinas Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antisense oligonucleotide therapy for Duchenne muscular dystrophy has shown great potential in preclinical and clinical trials, but its therapeutic applications are still limited due to inefficient delivery. In this study, we investigated a few polyquaterniums (PQs) with different size and composition for their potential to improve delivery performance of an antisense phosphorodiamidate morpholino oligomer (PMO) both in vitro and in vivo. The results showed that Luviquat

Indexed as

Drug Delivery SystemsAnimalsDystrophinExonsMiceMice, Inbred mdxMorpholinosOligonucleotides, AntisenseDystrophinMorpholinosOligonucleotides, Antisenseantisense deliveryexon-skippingmuscular dystrophyPMOPolyquaternium

Identifiers

PMID28633548
PMCPMC8241187
OpenAlexW2660223473

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.