ArticleTransactions of the Royal Society of Tropical Medicine and Hygiene2017
Pulmonary TB: varying radiological presentations in individuals with HIV in Soweto, South Africa.
Article in Transactions of the Royal Society of Tropical Medicine and Hygiene, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 29 citations in OpenAlex.
- Prospective Multi-Site Validation of AI to Detect Tuberculosis and Chest X-Ray Abnormalities.NEJM AI · 2024Article
- Higher plasma interleukin - 6 levels are associated with lung cavitation in drug-resistant tuberculosis.BMC immunology · 2023Article
- Association of circulating serum free bioavailable and total vitamin D with cathelicidin levels among active TB patients and household contacts.Scientific reports · 2023Article
- Chest X-ray findings in drug-sensitive and drug-resistant pulmonary tuberculosis patients in Uganda.Journal of clinical tuberculosis and other mycobacterial diseases · 2022Article
- The Impact of Tuberculosis on the Well-Being of Adolescents and Young Adults.Pathogens (Basel, Switzerland) · 2021Review
- Computer-aided interpretation of chest radiography reveals the spectrum of tuberculosis in rural South Africa.NPJ digital medicine · 2021Article
- Comparing rates of mycobacterial clearance in sputum smear-negative and smear-positive adults living with HIV.BMC infectious diseases · 2021Article
- Clinical manifestations and epidemiology of adolescent tuberculosis in Ukraine.ERJ open research · 2020Article
- Implementation science: point-of-care diagnostics in HIV and tuberculosis.Clinical medicine (London, England) · 2019Article
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
Abstract
Background: HIV-uninfected individuals with pulmonary TB (PTB) commonly present with radiological features of upper lobe cavitatory disease. In contrast, individuals with HIV and PTB may present differently. This study compared radiological features of individuals with laboratory-confirmed PTB by HIV status from the largest study in South Africa. Methods: We conducted a cross-sectional analysis of adults recruited between 2012 and 2015 with laboratory-confirmed PTB in Soweto, South Africa. Baseline characteristics and chest radiograph (CXR) findings were compared by χ2 test stratified by HIV status. Results: Of the 474 individuals with PTB, 348 (73.4%) had HIV. Individuals with HIV had a higher proportion of infiltrates (58.9% vs 46.8%, p=0.02) and a lower proportion of cavitations (40.8% vs 68.3%; p<0.0001) compared to HIV-uninfected individuals. Additionally, individuals with HIV had a lower proportion of cavitations sized ≥4 cm (16.7% vs 36.5%, p<0.001) and a lower proportion of disease extent involving half or more of the total lung area radiologically (25.9% vs 45.3%, p<0.0001). Conclusions: Individuals with HIV co-infected with PTB have a higher proportion of infiltrates and a lower proportion of cavitations relative to the HIV-uninfected PTB individuals. The absence of classical upper lobe cavitatory disease on CXR does not exclude PTB in individuals with HIV.
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