ArticlePloS one2017
Transient effects of transfusion and feeding advances (volumetric and caloric) on necrotizing enterocolitis development: A case-crossover study.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Stopping enteral feeds for prevention of transfusion-associated necrotising enterocolitis in preterm infants.The Cochrane database of systematic reviews · 2019Pooled it
- Timing of Red Blood Cell Transfusions and Occurrence of Necrotizing Enterocolitis: A Secondary Analysis of a Randomized Clinical Trial.JAMA network open · 2024Trial
- Transfusion-associated necrotising enterocolitis in very low birth weight babies: transfusion and feeding practices in two neonatal units in Bloemfontein, Free State.The Southern African journal of critical care : the official journal of the Critical Care Society · 2024Article
- The short-term effects of RBC transfusions on intestinal injury in preterm infants.Pediatric research · 2023Article
- Neonatal anemia relates to intestinal injury in preterm infants.Pediatric research · 2022Article
- Observational
- Framework for feature selection of predicting the diagnosis and prognosis of necrotizing enterocolitis.PloS one · 2022Article
- Transfusion in Neonatal Patients: Review of Evidence-Based Guidelines.Clinics in laboratory medicine · 2021Review
- Transfusion-related Gut Injury and Necrotizing Enterocolitis.Clinics in perinatology · 2020Review
- New insights into necrotizing enterocolitis: From laboratory observation to personalized prevention and treatment.Journal of pediatric surgery · 2019Review
- Epidemiology of Necrotizing Enterocolitis: New Considerations Regarding the Influence of Red Blood Cell Transfusions and Anemia.Clinics in perinatology · 2019Review
- Impact of red blood cell transfusions on intestinal barrier function in preterm infants.Journal of neonatal-perinatal medicine · 2019Article
- Does red blood cell irradiation and/or anemia trigger intestinal injury in premature infants with birth weight ≤ 1250 g? An observational birth cohort study.BMC pediatrics · 2018Observational
- Anemia, red blood cell transfusions, and necrotizing enterocolitis.Seminars in pediatric surgery · 2018Review
- The Association of Nil Per Os (NPO) Days with Necrotizing Enterocolitis.Gastroenterology research and practice · 2018Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
objectiveTo evaluate the short-term effects of feed fortification, feed volume increase, and PRBC transfusion on the odds of developing NEC. STUDY
designCase-crossover study of neonatal intensive care infants born at ≤ 32 weeks' gestation who were admitted to 5 central Ohio intensive care units from January 2012-July 2016 and developed NEC Bell Stage ≥2. Each patient served as their own control, with exposure during the 48-hour period just prior to NEC onset (hazard period) being compared to a preceding 48-hour control period, thus eliminating confounding by patient factors fixed between both intervals. NEC onset was determined by chart review as the earliest occurrence of one of the following within 24 hours of confirmatory x-ray: (1) antibiotic initiation, (2) enteral feeding cessation, (3) physician first notified of abdominal concerns, or (4) abdominal x-ray ordered. Conditional logistic regression compared exposures to feed volume increase, fortification, and PRBC transfusion during the 48-hour period prior to NEC onset to those during a preceding 48-hour control period. Analyses were stratified by gestational age and anemia (defined: hemoglobin ≤ 9.3 g/dL within 7 days of NEC onset).
resultsWe included 63 infants with confirmed NEC. Acute exposure to fortification (odds ratio [OR]: 1.67, 95% confidence interval [CI]: 0.61, 4.59), feed volume increase (OR: 0.63, 95% CI: 0.28, 1.38), and PRBC transfusion (OR: 1.80, 95% CI: 0.60, 5.37) was not associated with the onset of NEC. Gestational age and anemia did not significantly modify the associations. Sensitivity testing substituting 24- and 72-hour hazard and control periods produced similar results.
conclusionUsing a case-crossover design, we did not detect an association between NEC development and feed fortification, feed volume increase, or PRBC transfusion within 48-hours prior to NEC-onset. Replication in a larger set of cases is needed.
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