ArticlePLoS pathogens2017
Potassium is a key signal in host-microbiome dysbiosis in periodontitis.
Article in PLoS pathogens, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 61 citations in OpenAlex.
- Potassium in dental calculus as an indicator of diabetes.BMC oral health · 2026Article
- Examining Oral Microbial Communities at the Gingival Interface During Health and Inflammatory Diseases.Advances in experimental medicine and biology · 2026Review
- Longitudinal host-microbiome dynamics of metatranscription identify hallmarks of progression in periodontitis.Microbiome · 2025Article
- Cholesterol metabolism and intrabacterial potassium homeostasis are intrinsically related in Mycobacterium tuberculosis.PLoS pathogens · 2025Article
- The Effect of Environmental Factors on the Nitrate and Nitrite Metabolism of Oral Actinomyces and Schaalia Species.Molecular oral microbiology · 2025Article
- Peritoneal dialysis promotes microbial-driven biosynthesis pathways of sesquiterpenes and triterpenes compounds in end-stage renal disease patients.BMC microbiology · 2024Article
- Topical prebiotic nitrate: optimizing the 'hang-time', source and dose for specific oral or systemic effects.NPJ biofilms and microbiomes · 2024Article
- Periodontal changes induced by fixed orthodontic therapy.Medicine and pharmacy reports · 2024Article
- Editorial: Association between oral microbiota dysbiosis and the development of systemic conditions.Frontiers in cellular and infection microbiology · 2023Article
- Ancient dental calculus preserves signatures of biofilm succession and interindividual variation independent of dental pathology.PNAS nexus · 2022Article
- Comparing Ionic Profile of Gingival Crevicular Fluid and Saliva as Distinctive Signature of Severe Periodontitis.Biomedicines · 2022Article
- The association of healthy eating index with periodontitis in National Health and Nutrition Examination Study 2011-2012.Frontiers in nutrition · 2022Article
- TrkA serves as a virulence modulator inFrontiers in cellular and infection microbiology · 2022Article
- Advances in Experimental Research About Periodontitis: Lessons from the Past, Ideas for the Future.Advances in experimental medicine and biology · 2022Article
- Microbiota in Periodontitis: Advances in the Omic Era.Advances in experimental medicine and biology · 2022Review
- Complementary Experimental Methods in Genetics Open Up New Avenues of Research to Elucidate the Pathogenesis of Periodontitis.Advances in experimental medicine and biology · 2022Article
- Molecular Mechanisms for Bacterial Potassium Homeostasis.Journal of molecular biology · 2021Review
- Beyond Homeostasis: Potassium and Pathogenesis during Bacterial Infections.Infection and immunity · 2021Review
- Polymicrobial communities in periodontal disease: Their quasi-organismal nature and dialogue with the host.Periodontology 2000 · 2021Review
- Potential prebiotic substrates modulate composition, metabolism, virulence and inflammatory potential of an in vitro multi-species oral biofilm.Journal of oral microbiology · 2021Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
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Abstract
Dysbiosis, or the imbalance in the structural and/or functional properties of the microbiome, is at the origin of important infectious inflammatory diseases such as inflammatory bowel disease (IBD) and periodontal disease. Periodontitis is a polymicrobial inflammatory disease that affects a large proportion of the world's population and has been associated with a wide variety of systemic health conditions, such as diabetes, cardiovascular and respiratory diseases. Dysbiosis has been identified as a key element in the development of the disease. However, the precise mechanisms and environmental signals that lead to the initiation of dysbiosis in the human microbiome are largely unknown. In a series of previous in vivo studies using metatranscriptomic analysis of periodontitis and its progression we identified several functional signatures that were highly associated with the disease. Among them, potassium ion transport appeared to be key in the process of pathogenesis. To confirm its importance we performed a series of in vitro experiments, in which we demonstrated that potassium levels a increased the virulence of the oral community as a whole and at the same time altering the immune response of gingival epithelium, increasing the production of TNF-α and reducing the expression of IL-6 and the antimicrobial peptide human β-defensin 3 (hBD-3). These results indicate that levels of potassium in the periodontal pocket could be an important element in of dysbiosis in the oral microbiome. They are a starting point for the identification of key environmental signals that modify the behavior of the oral microbiome from a symbiotic community to a dysbiotic one.
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Registered trials
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