ArticlePloS one2017
Choroidal thickness in patients with coronary artery disease.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed, 80 citations in OpenAlex.
- Ophthalmological Microvascular Changes in ANOCA/INOCA Disease and Ophthalmological Methods to Detect Them-A Systematic Review.Journal of clinical medicine · 2026Review
- Article
- Correlation between diastolic function and fundus vascular features in coronary heart disease.International journal of ophthalmology · 2026Article
- Relation between systemic arteriosclerosis and choroidal blood flow in patients with acute coronary syndrome.Scientific reports · 2025Article
- Retinal and Choroidal Alterations in Heart Failure: A Systematic Review and Meta-analysis of OCT and OCT-A Findings with Emphasis on HFrEF.Ophthalmology and therapy · 2025Review
- Retinal Imaging as a Window into Cardiovascular Health: Towards Harnessing Retinal Analytics for Precision Cardiovascular Medicine.Journal of cardiovascular development and disease · 2025Review
- Relationship between choroidal structure and myocardial collateral flow regulation in acute and chronic coronary heart disease.International ophthalmology · 2025Observational
- Choroidal thickness as predictor of subclinical carotid atherosclerosis in adults with type 1 diabetes.Scientific reports · 2025Article
- A Pilot Study Investigating the Relationship Between Choroidal Thickness and Choroidal Vascular Index and Coronary Artery Ectasia.Diagnostics (Basel, Switzerland) · 2025Article
- The Use of Retinal Imaging Including Fundoscopy, OCT, and OCTA for Cardiovascular Risk Stratification and the Detection of Subclinical Atherosclerosis.Current atherosclerosis reports · 2025Review
- Choroidal vascularity index in health and systemic diseases: a systematic review.International journal of retina and vitreous · 2024Review
- Retinal vasculature changes in patients with internal carotid artery stenosis.International ophthalmology · 2024Article
- Non-Invasive Retinal Vessel Analysis as a Predictor for Cardiovascular Disease.Journal of personalized medicine · 2024Review
- Looking into the Eyes to See the Heart of Chronic Kidney Disease Patients.Life (Basel, Switzerland) · 2024Article
- Retinal Structural and Vascular Changes in Patients with Coronary Artery Disease: A Systematic Review and Meta-Analysis.Life (Basel, Switzerland) · 2024Review
- Internal Carotid Artery Stenosis and Ipsilateral Subretinal Drusenoid Deposits.Investigative ophthalmology & visual science · 2024Article
- Retinal Findings and Cardiovascular Risk: Prognostic Conditions, Novel Biomarkers, and Emerging Image Analysis Techniques.Journal of personalized medicine · 2023Review
- Impact of coronary artery bypass grafting surgery on the chorioretinal biomicroscopic characteristics.World journal of clinical cases · 2023Article
- Evaluation of Arterial Stiffness and Subfoveal Choroidal Thickness in Patients with Coronary Slow Flow.Acta Cardiologica Sinica · 2023Article
- Age-Related Macular Degeneration With Visual Disability Is Associated With Cardiovascular Disease Risk in the Korean Nationwide Cohort.Journal of the American Heart Association · 2023Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo evaluate choroidal thickness (CTh) in patients with coronary artery disease (CAD) compared to healthy controls.
designCross-sectional.
methodsSetting: Ambulatory clinic of a large city hospital. Patient population: Thirty-four patients had documented CAD, defined as history of >50% obstruction in at least one coronary artery on cardiac catheterization, positive stress test, ST elevation myocardial infarction, or revascularization procedure. Twenty-eight age-matched controls had no self-reported history of CAD or diabetes. Patients with high myopia, dense cataracts, and retinal disease were excluded. Observation procedures: Enhanced depth imaging optical coherence tomography and questionnaire regarding medical and ocular history. Main outcome measures: Subfoveal CTh and CTh 2000 μm superior, inferior, nasal, and temporal to the fovea in the left eye, measured by 2 readers.
resultsCTh was significantly lower in patients with CAD compared to controls at the subfoveal location (252 vs. 303 μm, P = 0.002) and at all 4 cardinal macular locations. The mean difference in CTh between the 2 groups ranged from 46 to 75 μm and was greatest in the inferior location. Within the CAD group, CTh was significantly lower temporally (P = 0.007) and nasally (P<0.001) than subfoveally, consistent with the pattern observed in controls. On multivariate analysis, CAD was negatively associated with subfoveal CTh (P = 0.006) after controlling for diabetes, hypertension, and hypercholesterolemia. CONCLUSIONS AND RELEVANCE: Patients with CAD have a thinner macular choroid than controls, with preservation of the normal spatial CTh pattern. Decreased CTh might predispose patients with CAD to high-risk phenotypes of age-related macular degeneration such as reticular pseudodrusen and could serve as a potential biomarker of disease in CAD.
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