ArticleBritish journal of cancer2017
Radiation-associated breast cancer and gonadal hormone exposure: a report from the Childhood Cancer Survivor Study.
Article in British journal of cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 5 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Breast cancer incidence and mortality in population studies of radiation exposure: systematic review and meta-analysis.British journal of cancer · 2026Pooled it
- International Recommendations for Screening and Preventative Practices for Long-Term Survivors of Transplantation and Cellular Therapy: A 2023 Update.Transplantation and cellular therapy · 2024Guideline
- Young Adult Cancer Survivorship: Recommendations for Patient Follow-up, Exercise Therapy, and Research.JNCI cancer spectrum · 2021Guideline
- Updated Breast Cancer Surveillance Recommendations for Female Survivors of Childhood, Adolescent, and Young Adult Cancer From the International Guideline Harmonization Group.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2020Guideline
- Management of Primary Ovarian Insufficiency Symptoms in Survivors of Childhood and Adolescent Cancer.Journal of the National Comprehensive Cancer Network : JNCCN · 2018Pooled it
- Endocrine late-effects in survivors of childhood and adolescence cancer: clinical management.Journal of endocrinological investigation · 2026Review
- Field cancerization, accelerated aging, and immunosuppression: the rapid rise of hormone-sensitive and early-onset breast cancer.NPJ breast cancer · 2025Review
- Long-term breast cancer risk post childhood cancer radiotherapy: data-driven screening recommendations for survivors.The British journal of radiology · 2025Article
- Prediction of breast cancer risk for adolescents and young adults with Hodgkin lymphoma.Journal of the National Cancer Institute · 2025Article
- Article
- International recommendations for screening and preventative practices for long-term survivors of transplantation and cellular therapy: a 2023 update.Bone marrow transplantation · 2024Review
- Subsequent female breast cancer risk associated with anthracycline chemotherapy for childhood cancer.Nature medicine · 2023Article
- Excellent results of screening for subsequent breast cancers in long-term survivors of childhood Hodgkin's lymphoma-Results of a population-based study.Frontiers in pediatrics · 2023Article
- Development and Validation of a Breast Cancer Risk Prediction Model for Childhood Cancer Survivors Treated With Chest Radiation: A Report From the Childhood Cancer Survivor Study and the Dutch Hodgkin Late Effects and LATER Cohorts.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2021Article
- Adaptations to a Generalized Radiation Dose Reconstruction Methodology for Use in Epidemiologic Studies: An Update from the MD Anderson Late Effect Group.Radiation research · 2019Article
- Hypogonadism in Children with a Previous History of Cancer: Endocrine Management and Follow-Up.Hormone research in paediatrics · 2019Review
- Incidence of Breast Cancer in the Life Span Study of Atomic Bomb Survivors: 1958-2009.Radiation research · 2018Article
- Reproductive Function and Outcomes in Female Survivors of Childhood, Adolescent, and Young Adult Cancer: A Review.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2018Review
- Risk, Risk Factors, and Surveillance of Subsequent Malignant Neoplasms in Survivors of Childhood Cancer: A Review.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2018Review
- Clinical and histological features of second breast cancers following radiotherapy for childhood and young adult malignancy.The British journal of radiology · 2018Article
Corrections and comments
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Authors and funding
16 authors at 10 institutions in 3 countries.
Funding
Abstract
backgroundThe relationship between hormone exposure and breast cancer risk in women treated with chest radiotherapy for childhood cancer is uncertain.
methodsParticipants included 1108 females from the Childhood Cancer Survivor Study who were diagnosed with childhood cancer 1970-1986, treated with chest radiotherapy, and survived to ages ⩾20 years. Hazard ratios (HRs) and 95% confidence intervals (CIs) from Cox models adjusted for chest radiation field, delivered dose, anthracycline exposure, and age at childhood cancer estimated risk.
resultsAmong 195 women diagnosed with breast cancer, 102 tumours were oestrogen-receptor positive (ER+). Breast cancer risk increased with ⩾10 years of ovarian function after chest radiotherapy vs <10 years (HR=2.89, CI 1.56-5.53) and for radiotherapy given within 1 year of menarche vs >1 year from menarche (HR=1.80, CI 1.19-2.72). Risk decreased with decreasing age at menopause (P
conclusionsEndogenous hormones are key contributors to breast cancer observed among childhood cancer survivors. Hormone therapy given for premature ovarian insufficiency does not fully replace the function that endogenous hormones have in breast cancer development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.