ReviewCurrent opinion in endocrinology, diabetes, and obesity2017
Persistent hypothyroid symptoms in a patient with a normal thyroid stimulating hormone level.
Review in Current opinion in endocrinology, diabetes, and obesity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 38 citations in OpenAlex.
- A Genetically-Engineered Thyroid Gland Built for Selective Triiodothyronine Secretion.International journal of molecular sciences · 2025Article
- Hypothyroidism, comorbidity and health-related quality of life: a population-based study.Endocrine connections · 2023Article
- Severity of hypothyroidism is inversely associated with impaired quality of life in patients referred to an endocrine clinic.Thyroid research · 2023Article
- Enhancing the Patient Voice: Quality of Life, Satisfaction, and Preference During Treatment of Hypothyroidism.Thyroid : official journal of the American Thyroid Association · 2022Article
- The Relationship between Gastrointestinal Health, Micronutrient Concentrations, and Autoimmunity: A Focus on the Thyroid.Nutrients · 2022Review
- Optimal Thyroid Hormone Replacement.Endocrine reviews · 2022Article
- Practical Guidelines for Diagnosing and Treating Thyroid Disease Based on the WOMED Metabolic Model of Disease Focusing on Glycolysis and Coenzyme QDiagnostics (Basel, Switzerland) · 2022Article
- Correlation between TSH levels and quality of life among subjects with well-controlled primary hypothyroidism.Endocrine · 2021Article
- Health-Related Quality of Life in Levothyroxine-Treated Hypothyroid Women and Women without Hypothyroidism: A Case-Control Study.Journal of clinical medicine · 2020Article
- Managing symptoms in hypothyroid patients on adequate levothyroxine: a narrative review.Endocrine connections · 2020Review
- Review
- Individualized Therapy for Hypothyroidism: Is T4 Enough for Everyone?The Journal of clinical endocrinology and metabolism · 2020Review
- No Effect of Thyroid Dysfunction and Autoimmunity on Health-Related Quality of Life and Mental Health in Children and Adolescents: Results From a Nationwide Cross-Sectional Study.Frontiers in endocrinology · 2020Article
- The ages and TSH values of patients being prescribed levothyroxine.Therapeutic advances in endocrinology and metabolism · 2020Article
- Patient Requests for Tests and Treatments Impact Physician Management of Hypothyroidism.Thyroid : official journal of the American Thyroid Association · 2019Article
- Thyroid hormone therapy for hypothyroidism.Endocrine · 2019Review
- Predicting Optimal Combination LT4 + LT3 Therapy for Hypothyroidism Based on Residual Thyroid Function.Frontiers in endocrinology · 2019Article
- Cognitive functioning and quality of life in patients with Hashimoto thyroiditis on long-term levothyroxine replacement.Endocrine · 2018Article
- An Online Survey of Hypothyroid Patients Demonstrates Prominent Dissatisfaction.Thyroid : official journal of the American Thyroid Association · 2018Article
- Lessons from Randomised Clinical Trials for Triiodothyronine Treatment of Hypothyroidism: Have They Achieved Their Objectives?Journal of thyroid research · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
purpose of reviewA subset of patients being treated for hypothyroidism do not feel well while taking levothyroxine (LT4) replacement therapy, despite having a normal serum thyroid stimulating hormone level. Pursuing a relative triiodothyronine deficiency as a potential explanation for patient dissatisfaction, has led to trials of combination therapy with liothyronine (LT3), with largely negative outcomes. This review attempts to reconcile these diverse findings, consider potential explanations, and identify areas for future research. RECENT
findingsPatients being treated with LT4 often have lower triiodothyronine levels than patients with endogenous thyroid function. Linking patient dissatisfaction with low triiodothyronine levels has fueled multiple combination therapy trials that have generally not shown improvement in patient quality of life, mood, or cognitive performance. Some trials, however, suggest patient preference for combination therapy. There continues, moreover, to be anecdotal evidence that patients have fewer unresolved symptoms while taking combination therapy. SUMMARY: The 14 trials completed to date have suffered from employing doses of LT3 that do not result in steady triiodothyronine levels, and having insufficient power to analyze results based on baseline dissatisfaction with therapy and patient genotype. Future trials that are able to incorporate such features may provide insight into what thyroid hormone preparations will most improve patient satisfaction with therapy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.