ArticleNature communications2017
Speckle-modulating optical coherence tomography in living mice and humans.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 58 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
58 citing papers in PubMed.
- Spatio-temporal optical coherence imaging and tomography forJournal of biomedical optics · 2026Review
- In vivo biomechanical property detection of the ciliary muscle based on optical coherence tomography and digital image correlation technology.Eye and vision (London, England) · 2026Article
- Enhancing biomedical optical volumetric imaging via self-supervised orthogonal learning.Science advances · 2026Article
- High-resolution dynamic full-field optical coherence microscopy: illuminating intracellular activity in deep tissue.Npj imaging · 2026Article
- Deep learning-enabled speckle reduction for cleared-sample coherent scattering tomography.bioRxiv : the preprint server for biology · 2026Article
- Cellular-resolution OCT reveals layer-specific retinal mosaics and ganglion cell degeneration in mouse retinaNeurophotonics · 2026Article
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- From Innovation to Application: Can Emerging Imaging Techniques Transform Breast Cancer Diagnosis?Diagnostics (Basel, Switzerland) · 2025Review
- Matrix-based imaging through dynamic scattering.Nature communications · 2025Article
- Label-free evaluation of mouse embryo quality using time-lapse bright field and optical coherence microscopy.Communications biology · 2025Article
- Enhanced penetration depth in optical coherence tomography and photoacoustic microscopyOptica · 2025Article
- Review
- Dual-parameter tomographic imaging of attenuation and backscattering coefficients for quantitative evaluation of immune cell-mediated cytotoxicity in tumor spheroids.Theranostics · 2025Article
- Multimodal mechano-microscopy reveals mechanical phenotypes of breast cancer spheroids in three dimensions.APL bioengineering · 2024Article
- Non-invasive estimation of the powder size distribution from a single speckle image.Light, science & applications · 2024Article
- Visible-Light Optical Coherence Tomography Fibergraphy of the Tree Shrew Retinal Ganglion Cell Axon Bundles.IEEE transactions on medical imaging · 2024Article
- High-speed reflectance confocal microscopy using speckle modulation.Biomedical optics express · 2024Article
- Permittivity tensor imaging: modular label-free imaging of 3D dry mass and 3D orientation at high resolution.Nature methods · 2024Article
- Revealing speckle obscured living human retinal cells with artificial intelligence assisted adaptive optics optical coherence tomography.Communications medicine · 2024Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors.
Funding
Abstract
Optical coherence tomography (OCT) is a powerful biomedical imaging technology that relies on the coherent detection of backscattered light to image tissue morphology in vivo. As a consequence, OCT is susceptible to coherent noise (speckle noise), which imposes significant limitations on its diagnostic capabilities. Here we show speckle-modulating OCT (SM-OCT), a method based purely on light manipulation that virtually eliminates speckle noise originating from a sample. SM-OCT accomplishes this by creating and averaging an unlimited number of scans with uncorrelated speckle patterns without compromising spatial resolution. Using SM-OCT, we reveal small structures in the tissues of living animals, such as the inner stromal structure of a live mouse cornea, the fine structures inside the mouse pinna, and sweat ducts and Meissner's corpuscle in the human fingertip skin-features that are otherwise obscured by speckle noise when using conventional OCT or OCT with current state of the art speckle reduction methods.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.