Evidence map›Paper›PMID 28632168›Full record

ArticleGenes2017

A Comparative Study of the Structural Dynamics of Four Terminal Uridylyl Transferases.

Kevin J Cheng, Özlem Demir, Rommie E Amaro

Abstract read
In one paragraph

Article in Genes, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kevin J ChengDepartment of Chemistry & Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA. kjcheng2@illinois.edu.
Özlem DemirDepartment of Chemistry & Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA. odemir@ucsd.edu.
Rommie E AmaroDepartment of Chemistry & Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA. ramaro@ucsd.edu.

Funding

National Biomedical Computation Resource - Competitive Revision SupplementP41GM103426 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI AMARO, ROMMIE E · 2012 to 2019
$14.0M
A Structural Systems Biology Approach to Drug DiscoveryDP2OD007237 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI AMARO, ROMMIE E · 2010 to 2015
$2.9M
NIGMS NIH HHS P41 GM103426NIH HHS DP2 OD007237
6 · The paper itself

Abstract

African trypanosomiasis occurs in 36 countries in sub-Saharan Africa with 10,000 reported cases annually. No definitive remedy is currently available and if left untreated, the disease becomes fatal. Structural and biochemical studies of trypanosomal terminal uridylyl transferases (TUTases) demonstrated their functional role in extensive uridylate insertion/deletion of RNA.

Indexed as

electrostaticsMEAT1pocket shapepocket volumePOVMERET1RET2terminal uridylyl transferasesTrypanosoma bruceiTUT4TUTases

Identifiers

PMID28632168
PMCPMC5485530

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.