Evidence map›Paper›PMID 28631947›Full record

ArticleChannels (Austin, Tex.)2017

Predominant contribution of L-type Cav1.2 channel stimulation to impaired intracellular calcium and cerebral artery vasoconstriction in diabetic hyperglycemia.

Stefano Morotti, Madeline Nieves-Cintrón, Matthew A Nystoriak, Manuel F Navedo, Eleonora Grandi

Open access · goldAbstract read
In one paragraph

Article in Channels (Austin, Tex.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. α1Journal of the American Heart Association · 2024
    Article
  3. Article
  4. Article
  5. Spatiotemporal Control of Vascular CaCirculation research · 2022
    Article
  6. Functional tuning of Vascular L-type CaFrontiers in physiology · 2022
    Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. A GeLife · 2019
    Article
  12. CaFrontiers in physiology · 2018
    Article
  13. Review
  14. Impaired BKScientific reports · 2017
    Article
  15. Frontiers in pharmacology · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Stefano Morottia Department of Pharmacology , University of California , Davis , CA , USA.ORCID http://orcid.org/0000-0001-8679-665X
Madeline Nieves-Cintróna Department of Pharmacology , University of California , Davis , CA , USA.ORCID http://orcid.org/0000-0003-1935-8400
Matthew A Nystoriaka Department of Pharmacology , University of California , Davis , CA , USA.ORCID http://orcid.org/0000-0001-8872-158X
Manuel F Navedoa Department of Pharmacology , University of California , Davis , CA , USA.ORCID http://orcid.org/0000-0001-6864-6594
Eleonora Grandia Department of Pharmacology , University of California , Davis , CA , USA.ORCID http://orcid.org/0000-0002-4401-8857
University of California, Davis · US

Funding

CARDIOVASCULAR RESEARCH TRAINING PROGRAMT32HL007828 · NHLBI · UNIVERSITY OF WASHINGTON · PI Francis Kim, Farid Moussavi-Harami · 1997 to 2026
$10.2M
Sex-specific arrhythmogenic mechanisms of atrial fibrillationR01HL131517 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Eleonora Grandi · 2016 to 2026
$5.0M
Coupling of Vascular Cav1.2 Channels In Health & DiseaseR01HL121059 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI NAVEDO, MANUEL F · 2015 to 2024
$4.5M
Calcium Sparklets-Induced Vascular Dysfunction During DiabetesR01HL098200 · NHLBI · UNIVERSITY OF WASHINGTON · PI NAVEDO, MANUEL F · 2010 to 2019
$3.5M
NHLBI NIH HHS R01 HL098200NHLBI NIH HHS R01 HL121059NHLBI NIH HHS R01 HL131517NHLBI NIH HHS T32 HL007828
6 · The paper itself

Abstract

Enhanced L-type Ca

Indexed as

Models, BiologicalCalciumCalcium Channels, L-TypeCalcium SignalingCaveolin 1Cerebral ArteriesDiabetes MellitusGlucoseHyperglycemiaIntracellular SpaceMembrane PotentialsMyocytes, Smooth MuscleProtein ConformationVasoconstrictionCalciumCalcium Channels, L-TypeCaveolin 1GlucoseL-type calcium channel alpha(1C)arterial myocytesdiabetesion channelsmathematical modelingsensitivity analysis

Identifiers

PMID28631947
PMCPMC5555263
OpenAlexW2586315212

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.