ArticleThe Journal of general virology2017
Nationwide overview of the distribution of hepatitis B virus genotypes in Brazil: a 1000-sample multicentre study.
Article in The Journal of general virology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Article
- SEROLOGICAL CLEARANCE OF HBSAG IN CHRONIC HEPATITIS B: EXPERIENCE IN A UNIVERSITY HOSPITAL.Arquivos de gastroenterologia · 2026Article
- First Detection of Hepatitis B Virus Subgenotype A5, and Characterization of Occult Infection and Hepatocellular Carcinoma-Related Mutations in Latin American and African Immigrants in Brazil.International journal of molecular sciences · 2024Article
- Genetic variability of hepatitis B virus in acute and in different phases of chronic infection in Brazil.Scientific reports · 2024Article
- Article
- Genetic diversity of hepatitis B virus quasispecies in different biological compartments reveals distinct genotypes.Scientific reports · 2023Article
- Hepatitis B Prevalence among Men Who Have Sex with Men in Brazil.Tropical medicine and infectious disease · 2023Article
- Regional differences and temporal trend analysis of Hepatitis B in Brazil.BMC public health · 2022Article
- Article
- Recent molecular evolution of hepatitis B virus genotype F in Latin America.Archives of virology · 2022Article
- Dried blood spot sampling for hepatitis B virus quantification, sequencing and mutation detection.Scientific reports · 2022Article
- Hepatitis B Virus Genotype G: The Odd Cousin of the Family.Frontiers in microbiology · 2022Review
- Clinico-epidemiological and sociodemographic profile of patients with hemophilia in the Brazilian Amazon: High prevalence of hepatitis C infection and its possible corrrelation with inhibitor development.Frontiers in public health · 2022Article
- Applicability of oral fluid samples for tracking hepatitis B virus mutations, genotyping, and phylogenetic analysis.Archives of virology · 2021Article
- Article
- Clinical, epidemiological aspects, and trends of Hepatitis B in Brazil from 2007 to 2018.Scientific reports · 2021Article
- Observational
- Hepatitis B virus genotypes prevalence in patients from hepatology services in Ceará, Brazil.Revista da Sociedade Brasileira de Medicina Tropical · 2021Article
- Hepatitis B in the Northwestern region of Sao Paulo State: genotypes and resistance mutations.Revista do Instituto de Medicina Tropical de Sao Paulo · 2021Article
- Deep sequencing applied to the analysis of viromes in patients with beta-thalassemia.Revista do Instituto de Medicina Tropical de Sao Paulo · 2021Article
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The influence of hepatitis B virus (HBV) genotypes in the natural history of the disease and its response to antiviral treatment have been addressed in many studies. In Brazil, studies on HBV genotype circulation have been restricted to specific population groups and states. Here, we have conducted a nationwide multicentre study with an unprecedented sample size representing all Brazilian regions in an effort to better understand the viral variants of HBV circulating among chronic carriers. Seven HBV genotypes were found circulating in Brazil. Overall, HBV/A was the most prevalent, identified in 589 (58.7 %) samples, followed by HBV/D (23.4 %) and HBV/F (11.3 %). Genotypes E, G, C and B were found in a minor proportion. The distribution of the genotypes differed markedly from the north to the south of the country. While HBV/A was the most prevalent in the North (71.6 %) and Northeast (65.0 %) regions, HBV/D was found in 78.9 % of the specimens analysed in the South region. HBV/F was the second most prevalent genotype in the Northeast region (23.5 %). It was detected in low proportions (7 to 10 %) in the North, Central-West and Southeast regions, and in only one sample in the South region. HBV/E was detected in all regions except in the South, while monoinfection with HBV/G was found countrywide, with the exception of Central-West states. Our sampling covered 24 of the 26 Brazilian states and the Federal District and is the first report of genotype distribution in seven states. This nationwide study provides the most complete overview of HBV genotype distribution in Brazil to date and reflects the origin and plurality of the Brazilian population.
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