SynthesisJournal of cellular and molecular medicine2017
Comparison of thiazide-like diuretics versus thiazide-type diuretics: a meta-analysis.
Synthesis in Journal of cellular and molecular medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- Comparative efficacy and safety of chlorthalidone and hydrochlorothiazide-meta-analysis.Journal of human hypertension · 2019Pooled it
- The effect of indapamide vs. bendroflumethiazide for primary hypertension: a systematic review.British journal of clinical pharmacology · 2019Pooled it
- The Effects of Oral Taurine on Resting Blood Pressure in Humans: a Meta-Analysis.Current hypertension reports · 2018Pooled it
- Efficacy and Safety of Fimasartan/Indapamide Combination Therapy versus Fimasartan Monotherapy in Patients with Essential Hypertension Inadequately Responding to Fimasartan 30 mg (FINEDUO): A Randomized, Double-Blind, Multicenter, Phase III Study.Drug design, development and therapy · 2026Trial
- Combination Therapy Is Superior to Sequential Monotherapy for the Initial Treatment of Hypertension: A Double-Blind Randomized Controlled Trial.Journal of the American Heart Association · 2017Trial
- Drug-Induced Hyponatremia Surveillance: A disproportionality analysis based on FAERs database.Pakistan journal of medical sciences · 2026Article
- Comparative efficacy and safety of chlorthalidoneWorld journal of cardiology · 2026Article
- Thiazide-Associated Hyponatremia: A Retrospective Cohort Study Comparing Hydrochlorothiazide Versus Indapamide Versus Chlorthalidone.Journal of clinical hypertension (Greenwich, Conn.) · 2025Article
- Diuretics: a review of the pharmacology and effects on glucose homeostasis.Frontiers in pharmacology · 2025Review
- Rationale for a New Low-Dose Triple Single Pill Combination for the Treatment of Hypertension.Global heart · 2024Article
- Thiazide Diuretic Utilization Within the VA.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2023Article
- Review
- Therapeutic roles of thiazides and loop diuretics in blood pressure control and renal protection against chronic kidney disease.Clinical hypertension · 2023Review
- Hyponatremia in patients with arterial hypertension: pathophysiology and management.Archives of medical science : AMS · 2023Article
- Comparison between the world health organization (WHO) and international society of hypertension (ISH) guidelines for hypertension.Annals of medicine · 2022Review
- Underutilization of Treatment for Black Adults With Apparent Treatment-Resistant Hypertension: JHS and the REGARDS Study.Hypertension (Dallas, Tex. : 1979) · 2020Article
- Thiazide Use and Decreased Risk of Heart Failure in Nondiabetic Patients Receiving Intensive Blood Pressure Treatment.Hypertension (Dallas, Tex. : 1979) · 2020Article
- A review of the prescribing trend of thiazide-type and thiazide-like diuretics in hypertension: A UK perspective.British journal of clinical pharmacology · 2019Review
- Thiazide Use and Cardiovascular Events in Type 2 Diabetic Patients With Well-Controlled Blood Pressure.Hypertension (Dallas, Tex. : 1979) · 2019Observational
- [Austrian Consensus on High Blood Pressure 2019].Wiener klinische Wochenschrift · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thiazide diuretics are widely used for the management of hypertension. In recent years, it has been actively debated that there is interchangeability of thiazide-type diuretics hydrochlorothiazide and thiazide-like diuretics including indapamide and chlorthalidone for the treatment of hypertension. With the purpose of seeking out the best thiazide diuretic for clinicians, we summarized the existing evidence on the two types of drugs and conducted a meta-analysis on their efficacy in lowering blood pressure and effects on blood electrolyte, glucose and total cholesterol. Twelve trials were identified: five based on the comparison of indapamide versus hydrochlorothiazide and seven based on the chlorthalidone versus hydrochlorothiazide. In the meta-analysis of blood pressure reduction, thiazide-like diuretics seemed to further reduce systolic BP ([95% CI]; -5.59 [-5.69, -5.49]; P < 0.001) and diastolic BP ([95% CI]; -1.98 [-3.29, -0.66]; P = 0.003). Meanwhile, in the analysis of side effects, the incidence of hypokalemia ([95% CI]; 1.58 [0.80, 3.12]; P = 0.19), hyponatremia ([95% CI]; -0.14 [-0.57, 0.30], P = 0.54), change of blood glucose ([95% CI];0.13 [-0.16, 0.41], P = 0.39) and total cholesterol ([95% CI]; 0.13 [-0.16, 0.41], P = 0.39) showed that there is no statistical significant differences between the two groups of drugs. In conclusion, using thiazide-like diuretics is superior to thiazide-type diuretics in reducing blood pressure without increasing the incidence of hypokalemia, hyponatraemia and any change of blood glucose and serum total cholesterol.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.