ArticleClinical rheumatology2017
Is there a relationship between serum ox-LDL, oxidative stress, and PON1 in knee osteoarthritis?
Article in Clinical rheumatology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Clinically Relevant Molecular Biomarkers for Use in Human Knee Osteoarthritis: A Systematic Review.Cartilage · 2021Pooled it
- Dyslipidemia Might Be Associated with an Increased Risk of Osteoarthritis.BioMed research international · 2020Pooled it
- Extra Virgin Olive Oil alleviates articular cartilage damage and reduces ox-LDL and oxidative stress in monosodium iodoacetate-induced osteoarthritis in rats.Clinical rheumatology · 2025Article
- Cellular and molecular mechanisms underlying obesity in degenerative spine and joint diseases.Bone research · 2024Review
- Preliminary results of clinical, biochemical, and radiological investigation into the oxidative status in patients with rotator cuff tendinopathy.Acta orthopaedica et traumatologica turcica · 2024Article
- Prevalence and risk factors of knee osteoarthritis: a cross-sectional survey in Nanjing, China.Frontiers in public health · 2024Article
- Antioxidant hydrogels for the treatment of osteoarthritis: mechanisms and recent advances.Frontiers in pharmacology · 2024Review
- Article
- Observational
- Causal Associations of Circulating Lipids with Osteoarthritis: A Bidirectional Mendelian Randomization Study.Nutrients · 2022Article
- Association of Serum Low-Density Lipoprotein, High-Density Lipoprotein, and Total Cholesterol With Development of Knee Osteoarthritis.Arthritis care & research · 2022Observational
- Fatty Acid-Binding Protein 4 (FABP4) Is Associated with Cartilage Thickness in End-Stage Knee Osteoarthritis.Cartilage · 2021Article
- Effects of Oral Hyaluronic Acid Administration in Dogs Following Tibial Tuberosity Advancement Surgery for Cranial Cruciate Ligament Injury.Animals : an open access journal from MDPI · 2021Article
- Mechanisms underlying direct actions of hyperlipidemia on myocardium: an updated review.Lipids in health and disease · 2020Review
- Thiol/disulfide homeostasis as a novel indicator of oxidative stress during the treatment process of patients with septic arthritis.Joint diseases and related surgery · 2020Article
- Investigation of oxidative stress markers and antioxidant enzymes activity in newly diagnosed type 2 diabetes patients and healthy subjects, association with IL-6 level.Journal of diabetes and metabolic disorders · 2019Article
- The Oxidative Stress in Knee Osteoarthritis Patients. An Attempt of Evaluation of Possible Compensatory Effects Occurring in the Disease Development.Medicina (Kaunas, Lithuania) · 2019Article
- Epistasis between ADIPOQ rs1501299 and PON1 rs662 polymorphisms is potentially associated with the development of knee osteoarthritis.Molecular biology reports · 2019Article
- Markers for oxidative stress in the synovial fluid of Thoroughbred horses with carpal bone fracture.Journal of equine science · 2019Article
- Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous in vitro studies have shown that oxidized low-density lipoprotein (ox-LDL) plays a role in the pathogenesis of osteoarthritis (OA). Paraoxonase-1 (PON1) protects both low-density lipoproteins (LDLs) and high-density lipoprotein (HDLs) against oxidative damage from circulating cells. In addition, PON1 is inactivated by ox-LDL and preserved by antioxidants. However, the relationship between serum ox-LDL, oxidative stress, and PON1 in knee OA remains unclear. Therefore, we investigated ox-LDL association with oxidative stress and PON1 in knee OA, and evaluated their relationships using radiological and clinical parameters. This study included 203 patients and 194 controls. The severity of OA was classified based on the Kellgren-Lawrence scoring system. In addition, each patient was clinically evaluated using the Western Ontario and McMaster University Osteoarthritis Index (WOMAC) score. Plasma concentrations of ox-LDL, oxidative stress markers, and PON1 were measured. Serum ox-LDL and oxidant parameters were significantly higher in patients compared to controls (p < 0.001 for all), whereas PON1 was significantly lower (p < 0.001). ox-LDL was inversely correlated with PON1, whereas it was positively correlated with radiographic severity, WOMAC score, and oxidant parameters. We found an association between the levels of various serum markers of oxidative injury, especially ox-LDL, and increasing severity of knee OA, as well as indirect evidence for their regulation by PON1. oxLDL seems to play a critical role in OA, both in the beginning, and during progression of, the disease. Therefore, serum oxLDL levels may be a helpful biomarker to evaluate the severity of knee OA.
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