Evidence map›Paper›PMID 28631013›Full record

ArticleJournal of materials science. Materials in medicine2017

In vivo evaluation of the bone integration of coated poly(vinyl-alcohol) hydrogel fiber implants.

David Moreau, Arthur Villain, Manon Bachy, Henry Proudhon, David N Ku, Didier Hannouche, Hervé Petite, Laurent Corté

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of materials science. Materials in medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

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  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

David MoreauMINES ParisTech, PSL Research University, MAT-Centre des Matériaux, CNRS UMR 7633, BP 87 91003, Evry, France.
Arthur VillainMINES ParisTech, PSL Research University, MAT-Centre des Matériaux, CNRS UMR 7633, BP 87 91003, Evry, France.
Manon BachyLaboratoire de Bioingénierie et Bioimagerie Ostéo-Articulaire (B2OA) CNRS UMR 7052, Université Denis Diderot Paris VII, 10 avenue de Verdun, Paris, 75010, France.
Henry ProudhonMINES ParisTech, PSL Research University, MAT-Centre des Matériaux, CNRS UMR 7633, BP 87 91003, Evry, France.
David N KuGeorge W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, 30332, USA.
Didier HannoucheLaboratoire de Bioingénierie et Bioimagerie Ostéo-Articulaire (B2OA) CNRS UMR 7052, Université Denis Diderot Paris VII, 10 avenue de Verdun, Paris, 75010, France.
Hervé PetiteLaboratoire de Bioingénierie et Bioimagerie Ostéo-Articulaire (B2OA) CNRS UMR 7052, Université Denis Diderot Paris VII, 10 avenue de Verdun, Paris, 75010, France.
Laurent CortéMINES ParisTech, PSL Research University, MAT-Centre des Matériaux, CNRS UMR 7633, BP 87 91003, Evry, France. laurent.corte@mines-paristech.fr.ORCID http://orcid.org/0000-0002-9732-3265
Centre National de la Recherche Scientifique · FRGeorgia Institute of Technology · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recently, it has been shown that constructs of poly(vinyl alcohol) (PVA) hydrogel fibers reproduce closely the tensile behavior of ligaments. However, the biological response to these systems has not been explored yet. Here, we report the first in vivo evaluation of these implants and focus on the integration in bone, using a rabbit model of bone tunnel healing. Implants consisted in bundles of PVA hydrogel fibers embedded in a PVA hydrogel matrix. Half of the samples were coated with a composite coating of hydroxyapatite (HA) particles embedded in PVA hydrogel. The biological integration was evaluated at 6 weeks using histology and micro-CT imaging. For all implants, a good biological tolerance and growth of new bone tissue are reported. All the implants were surrounded by a fibrous layer comparable to what was previously observed for poly(ethylene terephthalate) (PET) fibers currently used in humans for ligament reconstruction. An image analysis method is proposed to quantify the thickness of this fibrous capsule. Implants coated with HA were not significantly osteoconductive, which can be attributed to the slow dissolution of the selected hydroxyapatite. Overall, these results confirm the relevance of PVA hydrogel fibers for ligament reconstruction and adjustments are proposed to enhance its osseointegration.

Indexed as

Polyvinyl AlcoholProstheses and ImplantsAnimalsBiocompatible MaterialsBone and BonesDurapatiteExtracellular MatrixHydrogelsHydrolysisLigamentsMaleMaterials TestingOsseointegrationOsteolysisPolyethylene TerephthalatesRabbitsBiocompatible MaterialsDurapatiteHydrogelsPolyethylene TerephthalatesPolyvinyl Alcohol

Identifiers

PMID28631013
OpenAlexW2638956247

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.