ArticleScience advances2017
Differential intron retention in
Article in Science advances, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed.
- Trpv4 links environmental temperature to testicular differentiation in hermaphroditic ricefield eel.eLife · 2026Article
- Full-Length Transcriptome Comparison of Male and Female Gonads inBiomolecules · 2026Article
- Novel Method for Preparing Pseudo-Male Common Carp by Inducing Secondary Female-to-Male Sex Reversal Under High Temperature Conditions.Marine biotechnology (New York, N.Y.) · 2026Article
- RNA binding protein RBM20 regulates turtle temperature-dependent sex determination by repressing the splicing ofScience advances · 2025Article
- The Tree of Sex consortium: a global initiative for studying the evolution of reproduction in eukaryotes.Journal of evolutionary biology · 2025Article
- Metabolic acclimation to warming links unexpected immune activation and sexual dimorphism attenuation in Xenopus tropicalis.Communications biology · 2025Article
- Heat inducible nuclear translocation of Kdm6bb drives temperature dependent sex reversal in Nile tilapia.PLoS genetics · 2025Article
- Overexpression ofZoological research · 2024Article
- Thermoregulated transcriptomics: the molecular basis and biological significance of temperature-dependent alternative splicing.The Biochemical journal · 2024Review
- Experiencing short heat waves early in development changes thermal responsiveness of turtle embryos to later heat waves.The Journal of experimental biology · 2023Article
- Gene expression of male pathway genes sox9 and amh during early sex differentiation in a reptile departs from the classical amniote model.BMC genomics · 2023Article
- Molecular Cloning and Expression Responses ofGenes · 2022Article
- TruncatedScience advances · 2022Article
- Developmental dynamics of sex reprogramming by high incubation temperatures in a dragon lizard.BMC genomics · 2022Article
- CHARGE syndrome-associated proteins FAM172A and CHD7 influence male sex determination and differentiation through transcriptional and alternative splicing mechanisms.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022Article
- Sex-specific splicing of Z- and W-borneProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Genetic determination and JARID2 over-expression in a thermal incubation experiment in Casque-Headed Lizard.PloS one · 2022Article
- The life and death of RNA across temperatures.Computational and structural biotechnology journal · 2022Review
- Unraveling the genotype by environment interaction in a thermosensitive fish with a polygenic sex determination system.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In many vertebrates, sex of offspring is determined by external environmental cues rather than by sex chromosomes. In reptiles, for instance, temperature-dependent sex determination (TSD) is common. Despite decades of work, the mechanism by which temperature is converted into a sex-determining signal remains mysterious. This is partly because it is difficult to distinguish the primary molecular events of TSD from the confounding downstream signatures of sexual differentiation. We use the Australian central bearded dragon, in which chromosomal sex determination is overridden at high temperatures to produce sex-reversed female offspring, as a unique model to identify TSD-specific features of the transcriptome. We show that an intron is retained in mature transcripts from each of two
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