ArticleScience advances2017
Deregulated Ca
Open access · goldAbstract read
In one paragraph
Article in Science advances, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 9% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Genome-wide association analysis reveals insights into the genetic architecture of right ventricular structure and function.Nature genetics · 2022Pooled it
- Research progress on programmed cell death of cardiomyocytes in pressure-overload hypertrophic cardiomyopathy.Apoptosis : an international journal on programmed cell death · 2025Review
- Obscurin deficiency leads to compensated dilated cardiomyopathy and increased arrhythmias.The Journal of general physiology · 2025Article
- Experimental Models of Hypertrophic Cardiomyopathy: A Systematic Review.JACC. Basic to translational science · 2025Review
- Identification of Compound Heterozygous Variants in OBSCN Gene Associated With Rhabdomyolysis: A Case Report.Molecular genetics & genomic medicine · 2025Article
- Constitutive deletion of the obscurin-Ig58/59 domains induces atrial remodeling and Ca2+-based arrhythmogenesis.JCI insight · 2025Article
- Essential role of obscurin kinase-1 in cardiomyocyte coupling via N-cadherin phosphorylation.JCI insight · 2024Article
- PPP1R3A inhibits osteogenesis and negatively regulates intracellular calcium levels in calcific tendinopathy.iScience · 2023Article
- Cardiac Plin5 interacts with SERCA2 and promotes calcium handling and cardiomyocyte contractility.Life science alliance · 2023Article
- Alterations in cytoskeletal and CaFrontiers in cardiovascular medicine · 2023Article
- Structural and signaling proteins in the Z-disk and their role in cardiomyopathies.Frontiers in physiology · 2023Review
- Obscurin regulates ankyrin macromolecular complex formation.Journal of molecular and cellular cardiology · 2022Article
- Animal Models to Study Cardiac Arrhythmias.Circulation research · 2022Review
- Understanding the molecular basis of cardiomyopathy.American journal of physiology. Heart and circulatory physiology · 2022Review
- Impaired Intracellular CaInternational journal of molecular sciences · 2022Article
- Titin M-line insertion sequence 7 is required for proper cardiac function in mice.Journal of cell science · 2021Article
- Obscurin: A multitasking giant in the fight against cancer.Biochimica et biophysica acta. Reviews on cancer · 2021Review
- Molecular noise filtering in the β-adrenergic signaling network by phospholamban pentamers.Cell reports · 2021Article
- When is an obscurin variant pathogenic? The impact of Arg4344Gln and Arg4444Trp variants on protein-protein interactions and protein stability.Human molecular genetics · 2021Article
- Deletion of obscurin immunoglobulin domains Ig58/59 leads to age-dependent cardiac remodeling and arrhythmia.Basic research in cardiology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 2 institutions in 1 country.
Li-Yen R HuDepartment of Biochemistry and Molecular Biology, University of Maryland, Baltimore, Baltimore, MD 21201, USA.
Maegen A AckermannDepartment of Biochemistry and Molecular Biology, University of Maryland, Baltimore, Baltimore, MD 21201, USA.
Peter A HeckerDivision of Cardiovascular Medicine, Department of Medicine, University of Maryland, Baltimore, Baltimore, MD 21201, USA.
Benjamin L ProsserDepartment of Physiology, Center for Biomedical Engineering and Technology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.ORCID 0000-0003-3696-9131
Brendan KingDepartment of Biochemistry and Molecular Biology, University of Maryland, Baltimore, Baltimore, MD 21201, USA.
Kelly A O'ConnellDivision of Cardiovascular Medicine, Department of Medicine, University of Maryland, Baltimore, Baltimore, MD 21201, USA.
Alyssa GroganDepartment of Biochemistry and Molecular Biology, University of Maryland, Baltimore, Baltimore, MD 21201, USA.
Logan C MeyerDepartment of Chemistry and Biochemistry, James Madison University, Harrisonburg, VA 22807, USA.ORCID 0000-0003-4790-7251
Christopher E BerndsenDepartment of Chemistry and Biochemistry, James Madison University, Harrisonburg, VA 22807, USA.ORCID 0000-0002-4285-4341
Nathan T WrightDepartment of Chemistry and Biochemistry, James Madison University, Harrisonburg, VA 22807, USA.
W Jonathan LedererDepartment of Physiology, Center for Biomedical Engineering and Technology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.ORCID 0000-0002-8488-2180
Aikaterini Kontrogianni-KonstantopoulosDepartment of Biochemistry and Molecular Biology, University of Maryland, Baltimore, Baltimore, MD 21201, USA.
University of Maryland, Baltimore · USJames Madison University · US
Funding
Interdisciplinary Training Program Muscle BiologyT32AR007592 · NIAMS · UNIVERSITY OF MARYLAND BALTIMORE · PI Aikaterini Kontrogianni-Konstantopoulos · 1996 to 2026
$11.7MMultiscale spatiotemporal modeling of cardiac mitochondriaU01HL116321 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI JAFRI, MOHSIN SALEET, LEDERER, WILLIAM JONATHAN · 2014 to 2018
$3.5MStretch-Dependent Calcium Signaling in HeartR01HL106059 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI LEDERER, WILLIAM JONATHAN · 2011 to 2014
$1.5MNovel Locations; Familiar Functions: Obscurin at the Cardiac Intercalated DiscR00HL116778 · NHLBI · OHIO STATE UNIVERSITY · PI BORZOK, MAEGEN A. · 2016 to 2018
$729kStretch-dependent X-ROS signaling: implications for cardiomyopathyR00HL114879 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI PROSSER, BENJAMIN LEARS · 2014 to 2016
$728kStretch-dependent X-ROS signaling: implications for cardiomyopathyK99HL114879 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI PROSSER, BENJAMIN LEARS · 2012 to 2013
$269kNovel Locations; Familiar Functions: Obscurin at the Cardiac Intercalated DiscK99HL116778 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI BORZOK, MAEGEN A. · 2013 to 2014
$257kNHLBI NIH HHS K99 HL114879NHLBI NIH HHS K99 HL116778NHLBI NIH HHS R00 HL114879NHLBI NIH HHS R00 HL116778NHLBI NIH HHS R01 HL106059NHLBI NIH HHS U01 HL116321NIAMS NIH HHS T32 AR007592
Abstract
Obscurins are cytoskeletal proteins with structural and regulatory roles encoded by
Indexed as
Calcium SignalingMutationAnimalsArrhythmias, CardiacCalciumDisease Models, AnimalEchocardiographyElectrocardiographyGuanine Nucleotide Exchange FactorsHeart DiseasesMagnetic Resonance SpectroscopyMiceMice, TransgenicMuscle ProteinsProtein Serine-Threonine KinasesRho Guanine Nucleotide Exchange FactorsCalciumGuanine Nucleotide Exchange FactorsMuscle Proteinsobscn protein, mouseProtein Serine-Threonine KinasesRho Guanine Nucleotide Exchange FactorsarrhythmiaCa cyclingdilated cardiomyopahtyheart diseasehypertrophic cardiomyopahtyobscurinphospholambanpressure overloadtransaortic constriction
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.