Evidence map›Paper›PMID 28630913›Full record

ArticleScience advances2017

An innovative biologic system for photon-powered myocardium in the ischemic heart.

Jeffrey E Cohen, Andrew B Goldstone, Michael J Paulsen, Yasuhiro Shudo, Amanda N Steele, Bryan B Edwards, Jay B Patel, John W MacArthur, Michael S Hopkins, Casey E Burnett and 14 more

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 132 citations in OpenAlex.

  1. Review
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  11. Incorporation of photosynthetically active algal chloroplasts in cultured mammalian cells towards photosynthesis in animals.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2024
    Article
  12. Towards chlorocytes for therapeutic intravascular photosynthesis.Applied microbiology and biotechnology · 2024
    Review
  13. Article
  14. Review
  15. Sonosynthetic Cyanobacteria Oxygenation for Self-Enhanced Tumor-Specific Treatment.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  16. Biocompatibility ofInternational journal of molecular sciences · 2024
    Article
  17. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors at 2 institutions in 1 country.

Jeffrey E CohenDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Andrew B GoldstoneDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Michael J PaulsenDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Yasuhiro ShudoDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Amanda N SteeleDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Bryan B EdwardsDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Jay B PatelDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
John W MacArthurDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Michael S HopkinsDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0002-1973-5715
Casey E BurnettDivision of Blood and Marrow Transplantation, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Kevin J JaatinenDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0003-0010-8970
Akshara D ThakoreDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0002-3106-0159
Justin M FarryDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Vi N TruongDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Alexandra T BourdillonDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Lyndsay M StapletonDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Anahita EskandariDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Alexander S FairmanDepartment of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
William HiesingerDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Tatiana V EsipovaDepartment of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-1172-419X
William L PatrickDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Keven JiDepartment of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Judith A ShizuruDivision of Blood and Marrow Transplantation, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Y Joseph WooDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Stanford University · USUniversity of Pennsylvania · US

Funding

ANGIOGENIC TISSUE ENGINEERING TO LIMIT POST-INFARCTION VENTRICULAR REMODELINGR01HL089315 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI WOO, Y JOSEPH · 2008 to 2023
$6.4M
NHLBI NIH HHS R01 HL089315
6 · The paper itself

Abstract

Coronary artery disease is one of the most common causes of death and disability, afflicting more than 15 million Americans. Although pharmacological advances and revascularization techniques have decreased mortality, many survivors will eventually succumb to heart failure secondary to the residual microvascular perfusion deficit that remains after revascularization. We present a novel system that rescues the myocardium from acute ischemia, using photosynthesis through intramyocardial delivery of the cyanobacterium

Indexed as

Phototrophic ProcessesAnimalsBiological TherapyCyanobacteriaEnergy MetabolismHeart Function TestsHypoxiaMyocardial IschemiaMyocardiumMyocytes, CardiacPhotosynthesisRatsbioengineeringcoronary artery diseasecyanobacteriaischemic cardiomyopathyischemic heart diseasemyocardial infarctionphotosynthesisSymbiosisSynechococcus elongatustissue ischemia

Identifiers

PMID28630913
PMCPMC5470824
OpenAlexW2627027486

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.