ArticleScience advances2017
The GH receptor exon 3 deletion is a marker of male-specific exceptional longevity associated with increased GH sensitivity and taller stature.
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Article in Science advances, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
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Who cites it
30 citing papers in PubMed, 57 citations in OpenAlex.
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- The d3GHR carrier epigenome in Druze clan longevity.Scientific reports · 2024Article
- Targeting Cell Senescence and Senolytics: Novel Interventions for Age-Related Endocrine Dysfunction.Endocrine reviews · 2024Review
- DNA polymorphisms in inflammatory and endocrine signals linked to frailty are also associated with obesity: data from the FRASNET cohort.Frontiers in endocrinology · 2024Article
- Icariin Improves Stress Resistance and Extends Lifespan inInternational journal of molecular sciences · 2023Article
- The rosetta stone of successful ageing: does oral health have a role?Biogerontology · 2023Review
- The Exon 3-Deleted Growth Hormone Receptor (d3GHR) Polymorphism-A Favorable Backdoor Mechanism for the GHR Function.International journal of molecular sciences · 2023Review
- Hormones and Aging: An Endocrine Society Scientific Statement.The Journal of clinical endocrinology and metabolism · 2023Article
- Global changes in chromatin accessibility and transcription in growth hormone-secreting pituitary adenoma.Endocrine · 2022Article
- Growth Hormone, Not IGF-1 Is the Key Longevity Regulator in Mammals.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Common Pathogenetic Mechanisms Underlying Aging and Tumor and Means of Interventions.Aging and disease · 2022Article
- Physiological Systems in Promoting Frailty.Comprehensive Physiology · 2022Review
- Sex-specific phenotypic effects and evolutionary history of an ancient polymorphic deletion of the human growth hormone receptor.Science advances · 2021Article
- Order and disorder-An integrative structure of the full-length human growth hormone receptor.Science advances · 2021Article
- Article
- Study on the Reparative Effect of PEGylated Growth Hormone on Ovarian Parameters and Mitochondrial Function of Oocytes From Rats With Premature Ovarian Insufficiency.Frontiers in cell and developmental biology · 2021Article
- Redox-mediated regulation of aging and healthspan by an evolutionarily conserved transcription factor HLH-2/Tcf3/E2A.Redox biology · 2020Article
- Exceptionally Long-Lived Individuals (ELLI) Demonstrate Slower Aging Rate Calculated by DNA Methylation Clocks as Possible Modulators for Healthy Longevity.International journal of molecular sciences · 2020Article
Corrections and comments
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Authors and funding
16 authors at 7 institutions in 3 countries.
Danny Ben-AvrahamDepartment of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Diddahally R GovindarajuInstitute of Aging Research, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Temuri BudagovDepartment of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Delphine FradinINSERM U986, Pincus Building, Bicêtre Hospital, Paris Sud University, 94275 Le Kremlin Bicêtre, France.
Peter DurdaDepartment of Pathology University of Vermont, 208 South Park Drive, Colchester, VT 05446, USA.
Bing LiuLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA.
Sandy OttUniversity of Maryland School of Medicine, Baltimore, MD 21201, USA.
Danielle GutmanDepartment of Human Biology, Faculty of Natural Sciences, University of Haifa, Haifa, Israel.ORCID 0000-0001-9761-580X
Lital SharvitDepartment of Human Biology, Faculty of Natural Sciences, University of Haifa, Haifa, Israel.ORCID 0000-0002-2577-1907
Robert KaplanDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Pierre BougnèresINSERM U986, Pincus Building, Bicêtre Hospital, Paris Sud University, 94275 Le Kremlin Bicêtre, France.
Alex ReinerDepartment of Epidemiology, University of Washington School of Public Health, Seattle, WA 98195, USA.
Alan R ShuldinerUniversity of Maryland School of Medicine, Baltimore, MD 21201, USA.
Pinchas CohenLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA.
Nir BarzilaiDepartment of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Gil AtzmonDepartment of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Albert Einstein College of Medicine · USUniversité Paris-Sud · FRUniversity of Haifa · ILUniversity of Maryland, Baltimore · USUniversity of Southern California · USUniversity of Vermont · USUniversity of Washington · US
Funding
Systems BiologyU19AG023122 · NIA · TRANSLATIONAL GENOMICS RESEARCH INST · PI FRED H GAGE · 2004 to 2026
$102.6MTechnological Assessment and Solutions Core - RC4P30AG021334 · NIA · JOHNS HOPKINS UNIVERSITY · PI Jeremy D Walston · 2003 to 2026
$33.2MStable Isotope and Metabolomics CoreP60DK020541 · NIDDK · YESHIVA UNIVERSITY · PI PESSIN, JEFFREY E. · 1986 to 2014
$29.8MTranslational Research CoreP30DK020541 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI STREAMSON C CHUA · 2015 to 2026
$27.7MEinstein's Nathan Shock Center of Excellence in Basic Biology of AgingP30AG038072 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI HUFFMAN, DEREK MAJOR · 2010 to 2024
$10.8MROLE OF NUTRIENTS IN AGE-RELATED INSULIN RESISTANCEP01AG021654 · NIA · YESHIVA UNIVERSITY · PI SHAMOON, HARRY · 2003 to 2007
$10.6MThe Role of the Glucose-regulated Protein GRP78/BiP in Stress Resistance and AginP01AG034906 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MITCHELL, JAMES R. · 2011 to 2016
$9.3MCHS Events Follow-up StudyU01HL080295 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M · 2005 to 2008
$4.6MThrombosis Genetics, MI and Stroke in Older AdultsR01HL071862 · NHLBI · UNIVERSITY OF WASHINGTON · PI REINER, ALEXANDER P · 2003 to 2012
$4.3MDysregulation of Glucose Homeostasis in AgingR37AG018381 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI BARZILAI, NIR J · 2010 to 2019
$3.5MEpigenetic Profiling in Healthy Aging and Exceptional LongevityR01AG042188 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI ATZMON, GIL, BARZILAI, NIR J · 2011 to 2015
$2.0MGENOTYPING FOR LOCATING HUMAN DISEASE GENESN01HG065403 · NHGRI · JOHNS HOPKINS UNIVERSITY · PI VALLE, DAVID L · 1996 to 2000
$1.7MNHGRI NIH HHS N01 HG065403NHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC075150NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085086NHLBI NIH HHS R01 HL071862NHLBI NIH HHS U01 HL080295NIA NIH HHS P01 AG021654NIA NIH HHS P01 AG034906NIA NIH HHS P30 AG021334NIA NIH HHS P30 AG038072NIA NIH HHS R01 AG034430NIA NIH HHS R01 AG042188NIA NIH HHS R37 AG018381NIA NIH HHS U19 AG023122NIDDK NIH HHS P30 DK020541NIDDK NIH HHS P60 DK020541
Abstract
Although both growth hormone (GH) and insulin-like growth factor 1 (IGF-1) signaling were shown to regulate life span in lower organisms, the role of GH signaling in human longevity remains unclear. Because a GH receptor exon 3 deletion (
Indexed as
ExonsSequence DeletionBody HeightFemaleGenetic Association StudiesHuman Growth HormoneHumansInsulin-Like Growth Factor IKaplan-Meier EstimateLongevityMalePhenotypePolymorphism, GeneticQuantitative Trait, HeritableReceptors, SomatotropinHuman Growth HormoneIGF1 protein, humanInsulin-Like Growth Factor IReceptors, SomatotropinCentenariansd3-GHRgrowth hormone receptorIGF-Ilongevitypositive pleiotropy
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