ArticleScience advances2017
A D53 repression motif induces oligomerization of TOPLESS corepressors and promotes assembly of a corepressor-nucleosome complex.
Article in Science advances, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed.
- Structural basis of diverse substrate recruitment by the HIV-1 Vpr-hijacked CRL4(VprBP) E3 ligase.PLoS pathogens · 2026Article
- MYB Factors: Hubs of Plant Stress and Hormone Crosstalk.Plant biotechnology journal · 2026Review
- Towards an integrated molecular understanding of plant hormones.Journal of integrative plant biology · 2026Review
- β-Caryophyllene Competes With NINJA/IAAs for TOPLESS Family Corepressors to Regulate Plant Physiological Activities.Plant, cell & environment · 2026Article
- Strigolactone-mediated architecture regulation and stress resilience: Insights and innovations for crop breeding.Journal of integrative plant biology · 2026Review
- The TPR2 corepressor forms condensates with repressors to fine-tune growth and development in rice.The EMBO journal · 2026Article
- Phytohormonal Regulation of Plant Responses to Major Abiotic Stresses: From Signaling Pathways to Hormonal Crosstalk.Metabolites · 2026Review
- Article
- ERF.D2 negatively controls drought tolerance through synergistic regulation of abscisic acid and jasmonic acid in tomato.Plant biotechnology journal · 2025Article
- An N-terminal domain specifies developmental control by the SMAX1-LIKE family of transcriptional regulators inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Histone Modification-Dependent Transcriptional Regulation of Defence Genes in Early Response of Arabidopsis to Spodoptera litura Attack.Plant, cell & environment · 2025Article
- Functional Study ofInternational journal of molecular sciences · 2025Article
- The OsNL1-OsTOPLESS2-OsMOC1/3 pathway regulates high-order tiller outgrowth in rice.Plant biotechnology journal · 2025Article
- A function of TPL/TBL1-type corepressors is to nucleate the assembly of the preinitiation complex.The Journal of cell biology · 2025Article
- Suppression of SMXL4 and SMXL5 confers enhanced thermotolerance through promoting HSFA2 transcription in Arabidopsis.The Plant cell · 2024Article
- HTL/KAI2 signaling substitutes for light to control plant germination.PLoS genetics · 2024Article
- Strigolactone induces D14-dependent large-scale changes in gene expression requiring SWI/SNF chromatin remodellers.The Plant journal : for cell and molecular biology · 2024Article
- TaSPL6B, a member of the Squamosa promoter binding protein-like family, regulates shoot branching and florescence in Arabidopsis thaliana.BMC plant biology · 2024Article
- SUPPRESSOR OF MAX2 1-LIKE (SMXL) homologs are MAX2-dependent repressors of Physcomitrium patens growth.The Plant cell · 2024Article
- A conserved function of corepressors is to nucleate assembly of the transcriptional preinitiation complex.bioRxiv : the preprint server for biology · 2024Article
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Authors and funding
14 authors.
Funding
Abstract
TOPLESS are tetrameric plant corepressors of the conserved Tup1/Groucho/TLE (transducin-like enhancer of split) family. We show that they interact through their TOPLESS domains (TPDs) with two functionally important ethylene response factor-associated amphiphilic repression (EAR) motifs of the rice strigolactone signaling repressor D53: the universally conserved EAR-3 and the monocot-specific EAR-2. We present the crystal structure of the monocot-specific EAR-2 peptide in complex with the TOPLESS-related protein 2 (TPR2) TPD, in which the EAR-2 motif binds the same TPD groove as jasmonate and auxin signaling repressors but makes additional contacts with a second TPD site to mediate TPD tetramer-tetramer interaction. We validated the functional relevance of the two TPD binding sites in reporter gene assays and in transgenic rice and demonstrate that EAR-2 binding induces TPD oligomerization. Moreover, we demonstrate that the TPD directly binds nucleosomes and the tails of histones H3 and H4. Higher-order assembly of TPD complexes induced by EAR-2 binding markedly stabilizes the nucleosome-TPD interaction. These results establish a new TPD-repressor binding mode that promotes TPD oligomerization and TPD-nucleosome interaction, thus illustrating the initial assembly of a repressor-corepressor-nucleosome complex.
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