Evidence map›Paper›PMID 28630708›Full record

ReviewJournal of eating disorders2017

What happens after treatment? A systematic review of relapse, remission, and recovery in anorexia nervosa.

Sahib S Khalsa, Larissa C Portnoff, Danyale McCurdy-McKinnon, Jamie D Feusner

5 registry-linked trialsAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of eating disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 190 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
190citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03712384 completednot on this map

Personal Recovery of Young Adults With Severe Anorexia Nervosa During Adolescence: a Pilot Qualitative Study

TypeobservationalSponsorInstitut Mutualiste MontsourisRan2014 to 2014Enrolled5ConditionsAnorexia Nervosa, Eating DisorderArmsSemi structured face to face interview
NCT04191720 nacompletednot on this mapstarted 2018, after this paper: background citation

A Randomized Control Trial to Assess the Impact of Weighted Blankets on Anxiety Among Inpatients With Anorexia Nervosa and Avoidant Restrictive Food Intake Disorder: a Study Protocol

TypeinterventionalSponsorDenver Health and Hospital AuthorityRan2018 to 2019Enrolled24ConditionsAnorexia Nervosa, Avoidant/Restrictive Food Intake Disorder, AnxietyArmsWeighted blanket
NCT04564170 completednot on this mapstarted 2020, after this paper: background citation

Characterization and Relationship Between Eating Disorders and Autism Spectrum Disorders.

TypeobservationalSponsorFundació Institut de Recerca de l'Hospital de la Santa Creu i Sant PauRan2020 to 2024Enrolled135ConditionsEating Disorders
NCT06332963 narecruitingnot on this mapstarted 2024, after this paper: background citation

Interoceptive Mechanisms of Body Image Disturbance in Anorexia Nervosa

TypeinterventionalSponsorLaureate Institute for Brain Research, Inc.Ran2024 to 2028Enrolled102ConditionsAnorexia Nervosa, Body Image Disturbance, InteroceptionArmsFloatation-REST, IFT, EFT
NCT07169747 phase2recruitingnot on this mapstarted 2026, after this paper: background citation

The Therapeutic Potential of Psilocybin in Anorexia Nervosa in Young Adults

TypeinterventionalSponsorRegion SkaneRan2026 to 2027Enrolled40ConditionsAnorexia NervosaArmsPsilocybin
3 · Its place in the literature

Who cites it

190 citing papers in PubMed, 8 syntheses or guidelines pooled it.

  1. Defining Recovery and Relapse in Bulimia Nervosa: A Systematic Review of the Literature.European eating disorders review : the journal of the Eating Disorders Association · 2026
    Pooled it
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  5. The Follow-Up of Eating Disorders from Adolescence to Early Adulthood: A Systematic Review.International journal of environmental research and public health · 2022
    Pooled it
  6. A systematic review of outcomes following residential treatment for eating disorders.European eating disorders review : the journal of the Eating Disorders Association · 2020
    Pooled it
  7. Pooled it
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  9. Trial
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  11. Enhancing Motivation to Reduce Restrictive Eating: A Novel Approach.The International journal of eating disorders · 2025
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  18. Article
  19. Absence of Subliminal Body-Image Priming Effects in Anorexia Nervosa.The International journal of eating disorders · 2026
    Article
  20. Article

130 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sahib S KhalsaLaureate Institute for Brain Research, 6655 S Yale Ave, Tulsa, OK 74136 USA.
Larissa C PortnoffDepartment of Clinical Psychology, Teachers College, Columbia University, 525 W 120th St, New York, NY 10027 USA.
Danyale McCurdy-McKinnonDepartment of Pediatrics, The University of California Los Angeles, 757 Westwood Plaza, Los Angeles, CA 90095 USA.
Jamie D FeusnerDepartment of Psychiatry and Biobehavioral Sciences, The University of California Los Angeles, Semel Institute of Neuroscience and Human Behavior, 760 Westwood Plaza, Los Angeles, CA 90024 USA.

Funding

Anxiety and reward interaction and prediction of outcomes in anorexia nervosaR01MH105662 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FEUSNER, JAMIE · 2015 to 2019
$2.3M
Neural Basis of Meal Related Interoceptive Dysfunction in Anorexia NervosaK23MH112949 · NIMH · LAUREATE INSTITUTE FOR BRAIN RESEARCH · PI KHALSA, SAHIB · 2017 to 2021
$994k
NIMH NIH HHS K23 MH112949NIMH NIH HHS R01 MH105662
6 · The paper itself

Abstract

backgroundRelapse after treatment for anorexia nervosa (AN) is a significant clinical problem. Given the level of chronicity, morbidity, and mortality experienced by this population, it is imperative to understand the driving forces behind apparently high relapse rates. However, there is a lack of consensus in the field on an operational definition of relapse, which hinders precise and reliable estimates of the severity of this issue. The primary goal of this paper was to review prior studies of AN addressing definitions of relapse, as well as relapse rates.

methodsData sources included PubMed and PsychINFO through March 19th, 2016. A systematic review was performed following the PRISMA guidelines. A total of (

resultsDefinitions of relapse in AN as well as definitions of remission or recovery, on which relapse is predicated, varied substantially in the literature. Reported relapse rates ranged between 9 and 52%, and tended to increase with increasing duration of follow-up. There was consensus that risk for relapse in persons with AN is especially high within the first year following treatment. DISCUSSION: Standardized definitions of relapse, as well as remission and recovery, are needed in AN to accelerate clinical and research progress. This should improve the ability of future longitudinal studies to identify clinical, demographic, and biological characteristics in AN that predict relapse versus resilience, and to comparatively evaluate relapse prevention strategies. We propose standardized criteria for relapse, remission, and recovery, for further consideration.

Indexed as

Anorexia nervosaBulimia nervosaEating disorderOutcomePreventionRecoveryRelapseRemissionTreatment

Identifiers

PMID28630708
PMCPMC5470198

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.