ArticleJournal of animal science and biotechnology2017
Evidence of endometrial amino acid metabolism and transport modulation by peri-ovulatory endocrine profiles driving uterine receptivity.
Article in Journal of animal science and biotechnology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 44 citations in OpenAlex.
- Mechanism of Guilu Erxian ointment based on targeted metabolomics in interveningFrontiers in endocrinology · 2023Trial
- Metabolomic profiling of neat uterine luminal fluid in cows: local enrichment and nutritional modulation.The veterinary quarterly · 2026Article
- Metabolomic and transcriptomic landscape of the bovine uterine lumen during the second week of the estrous cycle.Journal of animal science and biotechnology · 2026Article
- Article
- Maternal supplementation of a Bacillus-based direct-fed microbials altered the cow prepartum plasma metabolome and the calf plasma metabolome before and after vaccination.Journal of animal science · 2025Article
- Mapping Expression Quantitative Trait Loci Targeting Candidate Genes for Pregnancy in Beef Cows.Biomolecules · 2024Article
- Article
- Administration of Beta-Nerve Growth Factor during the Preovulatory Stage Improves Endocrine and Luteal Function in Dairy Heifers.Animals : an open access journal from MDPI · 2023Article
- Article
- Machine Learning-Based Co-Expression Network Analysis Unravels Potential Fertility-Related Genes in Beef Cows.Animals : an open access journal from MDPI · 2022Article
- Preovulatory follicular fluid and serum metabolome profiles in lactating beef cows with thin, moderate, and obese body condition.Journal of animal science · 2022Article
- Progesterone-dependent and progesterone-independent modulation of luminal epithelial transcription to support pregnancy in cattle.Physiological genomics · 2022Article
- Endometrial receptivity in cattle: the mutual reprogramming paradigm.Animal reproduction · 2022Review
- Spatial and Pregnancy-Related Changes in the Protein, Amino Acid, and Carbohydrate Composition of Bovine Oviduct Fluid.International journal of molecular sciences · 2020Article
- Selenocysteine β-Lyase: Biochemistry, Regulation and Physiological Role of the Selenocysteine Decomposition Enzyme.Antioxidants (Basel, Switzerland) · 2019Review
- Bovine endometrium responds differentially to age-matched short and long conceptuses†.Biology of reproduction · 2019Article
- Changes in the uterine metabolome of the cow during the first 7 days after estrus.Molecular reproduction and development · 2019Article
- Metabolomics and pathway analyses to characterize metabolic alterations in pregnant dairy cows on D 17 and D 45 after AI.Scientific reports · 2018Article
- Perturbations in the uterine luminal fluid composition are detrimental to pregnancy establishment in cattle.Journal of animal science and biotechnology · 2018Article
- Sonogram of coccygeus muscle in dairy cows with different gestational ages.Journal of animal science and technology · 2017Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn beef cattle, changes in the periovulatory endocrine milieu are associated with fertility and conceptus growth. A large preovulatory follicle (POF) and the resulting elevated concentrations of progesterone (P4) during diestrus positively affect pregnancy rates. Amino acids (AA) are important components of maternally derived secretions that are crucial for embryonic survival before implantation. The hypothesis is that the size of the POF and the concentration of P4 in early diestrus modulate the endometrial abundance of SLC transcripts related to AA transport and metabolism and subsequently impact luminal concentrations of AA. The follicle growth of Nelore cows was manipulated to produce two experimental groups: large POF and CL (LF-LCL group) and small POF and CL (SF-SCL group). On Day 4 (D4; Experiment 1) and Day 7 (D7; Experiment 2) after GnRH-induced ovulation (GnRH treatment = D0), the animals were slaughtered and uterine tissues and uterine washings were collected. qRT-PCR was used to evaluate the expression levels of AA transporters in D4 and D7 endometrial tissues. The concentrations of AA were quantified in D4 and D7 uterine washings by HPLC.
resultsTranscript results show that, on D4,
conclusionThe present study revealed an association between the abundance of transcripts related to AA transport and metabolism in the endometrium and specific periovulatory endocrine profiles related to the receptive status of the mother. Such insights suggest that AAs are involved in uterine function to support embryo development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.