Evidence map›Paper›PMID 28630692›Full record

ReviewJournal of nutritional science2017

Liver fat: a relevant target for dietary intervention? Summary of a Unilever workshop.

Harry P F Peters, Patrick Schrauwen, Petra Verhoef, Christopher D Byrne, David J Mela, Andreas F H Pfeiffer, Ulf Risérus, Frits R Rosendaal, Vera Schrauwen-Hinderling

Registry-linked trialAbstract readReview
In one paragraph

Review in Journal of nutritional science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04520724 (The Production of a Functional Roll Supporting the Treatment of Non-alcoholic Fatty Liver Disease), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04520724 nacompletednot on this mapstarted 2018, after this paper: background citation

The Production of a Functional Roll Supporting the Treatment of Non-alcoholic Fatty Liver Disease (NAFLD)

TypeinterventionalSponsorPomeranian Medical University SzczecinRan2018 to 2019Enrolled50ConditionsNon-Alcoholic Fatty Liver DiseaseArmsplant fiber, maltodextrin bar
3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Harry P F PetersUnilever R&D Vlaardingen, Olivier van Noortlaan 120, Vlaardingen, The Netherlands.
Patrick SchrauwenDepartment of Human Biology, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, Maastricht, The Netherlands.
Petra VerhoefUnilever R&D Vlaardingen, Olivier van Noortlaan 120, Vlaardingen, The Netherlands.
Christopher D ByrneNutrition and Metabolism, Faculty of Medicine, University of Southampton & Southampton National Institute for Health Research Biomedical Research Centre, University Hospital Southampton, Southampton, UK.
David J MelaUnilever R&D Vlaardingen, Olivier van Noortlaan 120, Vlaardingen, The Netherlands.
Andreas F H PfeifferDepartment of Endocrinology, Diabetes and Nutrition, Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin.
Ulf RisérusDepartment of Public Health and Caring Sciences, Clinical Nutrition and Metabolism Unit, Uppsala University, Sweden.
Frits R RosendaalDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
Vera Schrauwen-HinderlingDepartment of Human Biology, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, Maastricht, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Currently it is estimated that about 1 billion people globally have non-alcoholic fatty liver disease (NAFLD), a condition in which liver fat exceeds 5 % of liver weight in the absence of significant alcohol intake. Due to the central role of the liver in metabolism, the prevalence of NAFLD is increasing in parallel with the prevalence of obesity, insulin resistance and other risk factors of metabolic diseases. However, the contribution of liver fat to the risk of type 2 diabetes mellitus and CVD, relative to other ectopic fat depots and to other risk markers, is unclear. Various studies have suggested that the accumulation of liver fat can be reduced or prevented via dietary changes. However, the amount of liver fat reduction that would be physiologically relevant, and the timeframes and dose-effect relationships for achieving this through different diet-based approaches, are unclear. Also, it is still uncertain whether the changes in liver fat

Indexed as

Cardiovascular diseaseDietDNL, de novo lipogenesisGI, glycaemic indexLiver fatMRS, magnetic resonance spectroscopyNAFLD, non-alcoholic fatty liver diseaseNASH, non-alcoholic steatohepatitisPET, positron emission tomographyPNPLA3, patatin-like phospholipase domain-containing protein 3 geneT2DM, type 2 diabetes mellitusType 2 diabetes

Identifiers

PMID28630692
PMCPMC5468740

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.