ArticleAnalytical methods : advancing methods and applications2016
Rapid Analysis of Trace Drugs and Metabolites Using a Thermal Desorption DART-MS Configuration.
Article in Analytical methods : advancing methods and applications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 82 citations in OpenAlex.
- Medicinal Amazonian Oleoresins: An Eco-Friendly Chemical Fingerprinting Method.Plants (Basel, Switzerland) · 2026Article
- Addressing the Oxygen in the Room: Exploring the Formation of Oxygenated Species for Nitazene Analogs Using DART-MS.Journal of the American Society for Mass Spectrometry · 2026Article
- Field and laboratory perspectives on fentanyl and carfentanil decontamination.Scientific reports · 2024Article
- Rapid screening of riot control agents using DART-TD-HRMS.Forensic toxicology · 2024Article
- Comparison of direct analysis in real-time mass spectrometry, atmospheric solids analysis probe-mass spectrometry, and ion mobility spectrometry for ensuring food safety by rapid screening of poppy seeds.Analytical and bioanalytical chemistry · 2024Article
- Rapid Chemical Screening of Microplastics and Nanoplastics by Thermal Desorption and Pyrolysis Mass Spectrometry with Unsupervised Fuzzy Clustering.Analytical chemistry · 2023Article
- Direct analysis in real-time mass spectrometry: Observations of helium, nitrogen and argon as ionisation gas for the detection of small molecules using a single quadrupole instrument.Rapid communications in mass spectrometry : RCM · 2023Article
- Non-invasive authentication of mail packages using nuclear quadrupole resonance spectroscopy.Scientific reports · 2023Article
- Utilization of Machine Learning for the Differentiation of Positional NPS Isomers with Direct Analysis in Real Time Mass Spectrometry.Analytical chemistry · 2022Article
- Confined DART-MS for Rapid Chemical Analysis of Electronic Cigarette Aerosols and Spiked Drugs.Journal of the American Society for Mass Spectrometry · 2021Article
- Creation and Release of an Updated NIST DART-MS Forensics Database.Journal of the American Society for Mass Spectrometry · 2021Article
- Forensic applications of DART-MS: A review of recent literature.Forensic chemistry (Amsterdam, Netherlands) · 2021Article
- Detection of trace drugs of abuse in baby formula using solid-phase microextraction direct analysis in real-time mass spectrometry (SPME-DART-MS).Journal of forensic sciences · 2021Article
- Analysis of benzodiazepines by thermal desorption direct analysis in real time mass spectrometry (TD-DART-MS).Analytical methods : advancing methods and applications · 2020Article
- Optimization of confined direct analysis in real time mass spectrometry (DART-MS).The Analyst · 2020Article
- What's in the bag? Analysis of exterior drug packaging by TD-DART-MS to predict the contents.Forensic science international · 2019Article
- Nitrogen-Activated Oxidation in Nitrogen Direct Analysis in Real Time Mass Spectrometry (DART-MS) and Rapid Detection of Explosives Using Thermal Desorption DART-MS.Journal of the American Society for Mass Spectrometry · 2019Article
- Detection of Brodifacoum and other Rodenticides in Drug Mixtures using Thermal Desorption Direct Analysis in Real Time Mass Spectrometry (TD-DART-MS).Journal of forensic sciences · 2019Article
- Forensic Analysis and Differentiation of Black Powder and Black Powder Substitute Chemical Signatures by Infrared Thermal Desorption-DART-MS.Analytical chemistry · 2019Article
- A multi-laboratory investigation of drug background levels.Forensic chemistry (Amsterdam, Netherlands) · 2019Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
Abstract
The need to analyze trace narcotic samples rapidly for screening or confirmatory purposes is of increasing interest to the forensic, homeland security, and criminal justice sectors. This work presents a novel method for the detection and quantification of trace drugs and metabolites off of a swipe material using a thermal desorption direct analysis in real time mass spectrometry (TD-DART-MS) configuration. A variation on traditional DART, this configuration allows for desorption of the sample into a confined tube, completely independent of the DART source, allowing for more efficient and thermally precise analysis of material present on a swipe. Over thirty trace samples of narcotics, metabolites, and cutting agents deposited onto swipes were rapidly differentiated using this methodology. The non-optimized method led to sensitivities ranging from single nanograms to hundreds of picograms. Direct comparison to traditional DART with a subset of the samples highlighted an improvement in sensitivity by a factor of twenty to thirty and an increase in reproducibility sample to sample from approximately 45 % RSD to less than 15 % RSD. Rapid extraction-less quantification was also possible.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.