Evidence map›Paper›PMID 28630527›Full record

ArticleDisease markers2017

A Promising Approach to Integrally Evaluate the Disease Outcome of Cerebral Ischemic Rats Based on Multiple-Biomarker Crosstalk.

Guimei Ran, Yixuan Wang, Haochen Liu, Chunxiang Wei, Tao Zhu, Haidong Wang, Hua He, Xiaoquan Liu

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Disease markers, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 96% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Guimei RanCenter of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, China.ORCID 0000-0003-1374-1345
Yixuan WangCenter of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, China.
Haochen LiuCenter of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, China.ORCID 0000-0001-6933-0073
Chunxiang WeiCenter of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, China.
Tao ZhuCenter of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, China.
Haidong WangCenter of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, China.
Hua HeCenter of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, China.
Xiaoquan LiuCenter of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, China.ORCID 0000-0001-8045-4501
China Pharmaceutical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe study was designed to evaluate the disease outcome based on multiple biomarkers related to cerebral ischemia.

methodsRats were randomly divided into sham, permanent middle cerebral artery occlusion, and edaravone-treated groups. Cerebral ischemia was induced by permanent middle cerebral artery occlusion surgery in rats. To form a simplified crosstalk network, the related multiple biomarkers were chosen as S100

resultsThe levels or activities of the related biomarkers and neurological deficit scores were significantly impacted by cerebral ischemia. The balance maps intuitively displayed the network disruption, and the integral disruption parameters quantitatively depicted the disruption state of the simplified network after cerebral ischemia. The integral disruption parameter

conclusionOur results indicate that the approach based on crosstalk network may provide a new promising way to integrally evaluate the outcome of cerebral ischemia.

Indexed as

Models, TheoreticalAnimalsBiomarkersBrain IschemiaEpoprostenolGlutathione PeroxidaseHypoxia-Inducible Factor 1, alpha SubunitInterleukin-1betaMaleRatsRats, Sprague-DawleyS100 Calcium Binding Protein beta SubunitThromboxane A2BiomarkersEpoprostenolGlutathione PeroxidaseHif1a protein, ratHypoxia-Inducible Factor 1, alpha SubunitInterleukin-1betaS100 Calcium Binding Protein beta SubunitThromboxane A2

Identifiers

PMID28630527
PMCPMC5463200
OpenAlexW2617833878

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.