ArticleScientific reports2017
Assessment of the role of intracranial hypertension and stress on hippocampal cell apoptosis and hypothalamic-pituitary dysfunction after TBI.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Influence of traumatic brain injury on serum levels of pituitary, thyroid, adrenal and gonadal hormones.Medicine · 2025Observational
- Transcriptomics and metabolomics reveal hypothalamic metabolic characteristics and key genes after subarachnoid hemorrhage in rats.Metabolic brain disease · 2024Article
- Atypical Terson syndrome after subarachnoid hemorrhage from middle cerebral artery aneurysm rupture during coitus.Surgical neurology international · 2024Article
- Endocrine Dysfunction After Traumatic Brain Injury: An Ignored Clinical Syndrome?Neurocritical care · 2023Review
- The Role of Apoptosis and Autophagy in the Hypothalamic-Pituitary-Adrenal (HPA) Axis after Traumatic Brain Injury (TBI).International journal of molecular sciences · 2022Article
- Pulmonary complications and respiratory management in neurocritical care: a narrative review.Chinese medical journal · 2022Review
- Prognostic Value of Circadian Brain Temperature Rhythm in Basal Ganglia Hemorrhage After Surgery.Neurology and therapy · 2021Article
- Prognostic Value of Circadian Rhythm of Brain Temperature in Traumatic Brain Injury.Journal of personalized medicine · 2021Article
- Ischemia-Modified Albumin: Origins and Clinical Implications.Disease markers · 2021Review
- Traumatic brain injuries induced pituitary dysfunction: a call for algorithms.Endocrine connections · 2020Review
- Neuroprotective Effects of Casein-Derived Peptide Met-Lys-Pro (MKP) in a Hypertensive Model.Frontiers in neuroscience · 2020Article
- Making sense of gut feelings in the traumatic brain injury pathogenesis.Neuroscience and biobehavioral reviews · 2019Review
- Xenon improves long-term cognitive function, reduces neuronal loss and chronic neuroinflammation, and improves survival after traumatic brain injury in mice.British journal of anaesthesia · 2019Article
- Pituitary pathology in traumatic brain injury: a review.Pituitary · 2019Review
- Traumatic brain injury and resultant pituitary dysfunction: insights from experimental animal models.Pituitary · 2019Review
- Radiological and endocrinological evaluations with grading of hypothalamic perifocal edema caused by craniopharyngiomas.Pituitary · 2019Article
- Cerebrospinal Fluid from Patients with Sporadic Amyotrophic Lateral Sclerosis Induces Degeneration of Motor Neurons Derived from Human Embryonic Stem Cells.Molecular neurobiology · 2019Article
- Anti-TNF-alpha antibody attenuates subarachnoid hemorrhage-induced apoptosis in the hypothalamus by inhibiting the activation of Erk.Neuropsychiatric disease and treatment · 2018Article
- Neuroendocrine Abnormalities Following Traumatic Brain Injury: An Important Contributor to Neuropsychiatric Sequelae.Frontiers in endocrinology · 2018Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In recent years, hypopituitarism caused by traumatic brain injury (TBI) has been explored in many clinical studies; however, few studies have focused on intracranial hypertension and stress caused by TBI. In this study, an intracranial hypertension model, with epidural hematoma as the cause, was used to explore the physiopathological and neuroendocrine changes in the hypothalamic-pituitary axis and hippocampus. The results demonstrated that intracranial hypertension increased the apoptosis rate, caspase-3 levels and proliferating cell nuclear antigen (PCNA) in the hippocampus, hypothalamus, pituitary gland and showed a consistent rate of apoptosis within each group. The apoptosis rates of hippocampus, hypothalamus and pituitary gland were further increased when intracranial pressure (ICP) at 24 hour (h) were still increased. The change rates of apoptosis in hypothalamus and pituitary gland were significantly higher than hippocampus. Moreover, the stress caused by surgery may be a crucial factor in apoptosis. To confirm stress leads to apoptosis in the hypothalamus and pituitary gland, we used rabbits to establish a standard stress model. The results confirmed that stress leads to apoptosis of neuroendocrine cells in the hypothalamus and pituitary gland, moreover, the higher the stress intensity, the higher the apoptosis rate in the hypothalamus and pituitary gland.
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