Evidence map›Paper›PMID 28630469›Full record

ArticleScientific reports2017

C2238 ANP gene variant promotes increased platelet aggregation through the activation of Nox2 and the reduction of cAMP.

Roberto Carnevale, Pasquale Pignatelli, Giacomo Frati, Cristina Nocella, Rosita Stanzione, Daniele Pastori, Simona Marchitti, Valentina Valenti, Maria Santulli, Emanuele Barbato and 7 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01882114 (Study of Atherosclerotic Risk Factors and Oxidative Stress in Atrial Fibrillation. Relation to Cardiovascular Events), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01882114 unknown statusnot on this map

Study of Atherosclerotic Risk Factors and Oxidative Stress in Atrial Fibrillation. Relation to Cardiovascular Events

TypeobservationalSponsorUniversity of Roma La SapienzaRan2007 to 2020Enrolled3,000ConditionsAtrial Fibrillation, Metabolic Syndrome, Oxidative Stress, Atherosclerosis
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Genetic variations in the transcription factorsDrug design, development and therapy · 2019
    Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 2 countries.

Roberto CarnevaleDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100, Latina (LT), Italy.
Pasquale PignatelliDepartment of Internal Medicine and Medical Specialties, Sapienza University of Rome, 00161, Rome (RM), Italy.
Giacomo FratiDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100, Latina (LT), Italy.
Cristina NocellaDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100, Latina (LT), Italy.
Rosita StanzioneDepartment of AngioCardioNeurology, IRCCS Neuromed, 86077, Pozzilli (IS), Italy.
Daniele PastoriDepartment of Internal Medicine and Medical Specialties, Sapienza University of Rome, 00161, Rome (RM), Italy.
Simona MarchittiDepartment of AngioCardioNeurology, IRCCS Neuromed, 86077, Pozzilli (IS), Italy.
Valentina ValentiDepartment of Imaging, Bambino Gesù Children Hospital, IRCCS, Rome, Italy.
Maria SantulliDepartment of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
Emanuele BarbatoCardiovascular Center Aalst, Onze-Lieve-Vrouw Hospital, Aalst, Belgium.
Teresa StrisciuglioDivision of Cardiology, Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy.
Leonardo SchironeDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100, Latina (LT), Italy.
Carmine VecchioneDepartment of AngioCardioNeurology, IRCCS Neuromed, 86077, Pozzilli (IS), Italy.
Francesco VioliDepartment of Internal Medicine and Medical Specialties, Sapienza University of Rome, 00161, Rome (RM), Italy.
Massimo VolpeDepartment of AngioCardioNeurology, IRCCS Neuromed, 86077, Pozzilli (IS), Italy.ORCID 0000-0002-9642-8380
Speranza RubattuDepartment of AngioCardioNeurology, IRCCS Neuromed, 86077, Pozzilli (IS), Italy. rubattu.speranza@neuromed.it.
Sebastiano SciarrettaDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100, Latina (LT), Italy. sebastiano.sciarretta@uniroma1.it.
Sapienza University of Rome · ITIstituto Neurologico Mediterraneo · ITBambino Gesù Children's Hospital · ITOnze Lieve Vrouwziekenhuis Hospital · BEUniversity of Naples Federico II · ITUniversity of Salerno · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Subjects carrying the C2238 variant of the atrial natriuretic peptide (ANP) gene have a higher occurrence of stroke and acute coronary syndrome, suggesting an increased predisposition to acute thrombotic events in these subjects. We evaluated for the first time the direct effects of mutant ANP (C2238/αANP) on platelet activation in vitro and in human subjects. In vitro, platelets were incubated with no peptide, with T2238/αANP (WT) or with C2238/αANP at different concentrations. C2238/αANP (10

Indexed as

Atrial Natriuretic FactorMutation, MissensePlatelet AggregationAtrial FibrillationBlood PlateletsCyclic AMPFemaleHumansMaleNADPH Oxidase 2Atrial Natriuretic FactorCYBB protein, humanCyclic AMPNADPH Oxidase 2

Identifiers

PMID28630469
PMCPMC5476672
OpenAlexW2626288180

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.