Trial reportScientific reports2017
Gut microbiota of liver transplantation recipients.
Trial report in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed.
- Beyond the Graft: Optimizing Post-Transplant Care in Primary Sclerosing Cholangitis.Journal of clinical medicine · 2026Review
- Geography-independent mucosal microbiota alterations in primary sclerosing cholangitis persist after liver transplantation.JHEP reports : innovation in hepatology · 2026Article
- Postoperative gut dysbiosis in biliary atresia patients treated by portoenterostomy or liver transplantation.Pediatric surgery international · 2025Article
- Unusual Localization of PresumptivePathogens (Basel, Switzerland) · 2025Article
- The gut microbiota in liver transplantation recipients during the perioperative and postoperative recovery period.Frontiers in microbiology · 2025Article
- Gut microbiota influence on lung cancer risk through blood metabolite mediation: from a comprehensive Mendelian randomization analysis and genetic analysis.Frontiers in nutrition · 2024Article
- Intestinal dysbiosis as an intraoperative predictor of septic complications: evidence from human surgical cohorts and preclinical models of peritoneal sepsis.Scientific reports · 2023Article
- Gut Microbiota and Liver Transplantation: Immune Mechanisms behind the Rejection.Biomedicines · 2023Review
- Research Progress of Fecal Microbiota Transplantation in Liver Diseases.Journal of clinical medicine · 2023Review
- Article
- Gut microbiome dysbiosis in the setting of solid organ transplantation: What we have gleaned from human and animal studies.World journal of transplantation · 2022Review
- Biliary Diseases from the Microbiome Perspective: How Microorganisms Could Change the Approach to Benign and Malignant Diseases.Microorganisms · 2022Review
- Immunotherapy in liver transplantation for hepatocellular carcinoma: Pros and cons.World journal of gastrointestinal oncology · 2022Review
- Dysbiosis and Depletion of Fecal Organic Acids Correlate With the Severity of Rejection After Rat Liver Transplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2022Article
- Editorial: The Microbiome in Hepatobiliary and Intestinal Disease.Frontiers in physiology · 2022Article
- The Gut Microbiota in Liver Transplantation Recipients During the Perioperative Period.Frontiers in physiology · 2022Article
- Comprehensive Analysis of Gut Microbiota and Fecal Bile Acid Profiles in Children With Biliary Atresia.Frontiers in cellular and infection microbiology · 2022Article
- Hepatocellular Cancer and Gut Microbiome: Time to Untie Gordian's Knot.Journal of gastrointestinal cancer · 2021Review
- The Interplay between Gut Microbiota and the Immune System in Liver Transplant Recipients and Its Role in Infections.Infection and immunity · 2021Review
- COVID-19 in Liver Transplant Recipients: A Systematic Review.Journal of clinical medicine · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The characteristics of intestinal microbial communities may be affected by changes in the pathophysiology of patients with end-stage liver disease. Here, we focused on the characteristics of intestinal fecal microbial communities in post-liver transplantation (LT) patients in comparison with those in the same individuals pre-LT and in healthy individuals. The fecal microbial communities were analyzed via MiSeq-PE250 sequencing of the V4 region of 16S ribosomal RNA and were then compared between groups. We found that the gut microbiota of patients with severe liver disease who were awaiting LT was significantly different from that of healthy controls, as represented by the first principal component (p = 0.0066). Additionally, the second principal component represented a significant difference in the gut microbiota of patients between pre-LT and post-LT surgery (p = 0.03125). After LT, there was a significant decrease in the abundance of certain microbial species, such as Actinobacillus, Escherichia, and Shigella, and a significant increase in the abundance of other microbial species, such as Micromonosporaceae, Desulfobacterales, the Sarcina genus of Eubacteriaceae, and Akkermansia. Based on KEGG profiles, 15 functional modules were enriched and 21 functional modules were less represented in the post-LT samples compared with the pre-LT samples. Our study demonstrates that fecal microbial communities were significantly altered by LT.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.