ArticleScientific reports2017
A genome-wide association study of anorexia nervosa suggests a risk locus implicated in dysregulated leptin signaling.
Erratum issuedOpen access · goldAbstract read
In one paragraph
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers.
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0cells of the map it votes in
19citing papers in PubMed
4.2field-weighted citation impact, top 6% of its field
What it found
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Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- Balancing acts: lateral hypothalamic circuits coordinating feeding, anxiety, and social interactions.Reviews in endocrine & metabolic disorders · 2026Review
- Psychopathology and Other Mental Health Challenges in Siblings of Patients with Child- or Adolescent-Onset Anorexia Nervosa: A Systematic Review with a Sex/Gender Perspective.Journal of clinical medicine · 2026Review
- A lateral hypothalamic neuronal population expressing leptin receptors counteracts anxiety to enable adaptive behavioral responses.Nature neuroscience · 2025Article
- Descriptives and Genetic Correlates of Eating Disorder Diagnostic Transitions and Presumed Remission in the Danish Registry.Biological psychiatry · 2025Article
- Psychiatric genetics in the diverse landscape of Latin American populations.Nature genetics · 2025Review
- Descriptives and genetic correlates of eating disorder diagnostic transitions and presumed remission in the Danish registry.medRxiv : the preprint server for health sciences · 2024Article
- Understanding the Consequences of Fatty Bone and Fatty Muscle: How the Osteosarcopenic Adiposity Phenotype Uncovers the Deterioration of Body Composition.Metabolites · 2023Review
- Eating disorder symptoms and their associations with anthropometric and psychiatric polygenic scores.European eating disorders review : the journal of the Eating Disorders Association · 2022Article
- Article
- Epigenetics of functional hypothalamic amenorrhea.Frontiers in endocrinology · 2022Review
- Stressful life events among individuals with a history of eating disorders: a case-control comparison.BMC psychiatry · 2021Article
- The association between leptin and weight maintenance outcome in anorexia nervosa.The International journal of eating disorders · 2021Article
- Increased plasma asprosin levels in patients with drug-naive anorexia nervosa.Eating and weight disorders : EWD · 2021Article
- Nipping Adipocyte Inflammation in the Bud.Immunometabolism · 2021Article
- Suggestive Evidence for Causal Effect of Leptin Levels on Risk for Anorexia Nervosa: Results of a Mendelian Randomization Study.Frontiers in genetics · 2021Article
- Genetic contributions to the etiology of anorexia nervosa: New perspectives in molecular diagnosis and treatment.Molecular genetics & genomic medicine · 2020Review
- Eating Disorders, Heredity and Environmental Activation: Getting Epigenetic Concepts into Practice.Journal of clinical medicine · 2020Review
- Anorexia Nervosa and the Immune System-A Narrative Review.Journal of clinical medicine · 2019Review
- Genetic risk factors for eating disorders: an update and insights into pathophysiology.Therapeutic advances in psychopharmacology · 2019Review
Corrections and comments
- Erratum issued
Authors and funding
28 authors at 20 institutions in 18 countries.
Dong LiCenter for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA. lid2@email.chop.edu.
Xiao ChangCenter for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
John J ConnollyCenter for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Lifeng TianCenter for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Yichuan LiuCenter for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Elizabeth J BhojCenter for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Nora RobinsonCenter for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Debra AbramsCenter for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Yun R LiCenter for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Jonathan P BradfieldCenter for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Cecilia E KimCenter for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Jin LiCenter for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Fengxiang WangCenter for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
James SnyderCenter for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Maria LemmaCenter for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Cuiping HouCenter for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Zhi WeiCenter for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Yiran GuoCenter for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID 0000-0002-6549-8589
Haijun QiuCenter for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Frank D MentchCenter for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Kelly A ThomasCenter for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Rosetta M ChiavacciCenter for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Roger ConeDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA.
Bingshan LiDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA.
Patrick A SleimanCenter for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Eating Disorders Working Group of the Psychiatric Genomics Consortium
Price Foundation Collaborative Group
Hakon HakonarsonCenter for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA. hakonarson@chop.edu.
Children's Hospital of Philadelphia · USUniversity of North Carolina at Chapel Hill · USWellcome Sanger Institute · GBMedical University of Vienna · ATUniversity of Padua · ITUniversity of Helsinki · FICentre for Addiction and Mental Health · CAInserm · FRKing's College London · GBUniversity Medical Center Utrecht · NLCharles University · CZHospital del Mar Research Institute · ESUniversity of Tartu · EEEssen University Hospital · DEHarokopio University of Athens · GRKarolinska Institutet · SEOslo University Hospital · NOPoznan University of Medical Sciences · PLUniversity of Bergen · NOUniversity of Naples Federico II · IT
Funding
Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3MPostdoctoral Research Training in Eating DisordersT32MH076694 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BULIK, CYNTHIA M · 2007 to 2016
$1.8MBIOMARKERS OF WEIGHT CHANGE IN ANOREXIA NERVOSAK01MH106675 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BAKER, JESSICA H · 2016 to 2019
$651kShared Genetic and Environmental Risk Factors for Anorexia Nervosa and Obsessive-Compulsive Disorder in DenmarkK01MH109782 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI YILMAZ, ZEYNEP · 2016 to 2019
$620kDevelopmental Psychopathology of Restrictive and Binge Eating in ChildhoodK01MH100435 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ZERWAS, STEPHANIE CHRISTINE · 2013 to 2015
$488kNIDDK NIH HHS P30 DK020572NIMH NIH HHS K01 MH100435NIMH NIH HHS K01 MH106675NIMH NIH HHS K01 MH109782NIMH NIH HHS T32 MH076694
Abstract
We conducted a genome-wide association study (GWAS) of anorexia nervosa (AN) using a stringently defined phenotype. Analysis of phenotypic variability led to the identification of a specific genetic risk factor that approached genome-wide significance (rs929626 in EBF1 (Early B-Cell Factor 1); P = 2.04 × 10
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.