ArticleProceedings of the National Academy of Sciences of the United States of America2017
How selective severing by katanin promotes order in the plant cortical microtubule array.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed.
- KATANIN is required for the formation of complete preprophase bands and subsequent division positioning in two asymmetric divisions of the maize stomatal complex.Journal of cell science · 2026Article
- KATANIN promotes cell elongation and division to generate proper cell numbers in maize organs.Nature communications · 2026Article
- Conflicting roles of cell geometry, microtubule deflection, and orientation-dependent dynamic instability in cortical array organization.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Microtubule-based nucleation results in a large sensitivity to cell geometry of the plant cortical array.PLoS computational biology · 2025Article
- Microtubule flexibility, microtubule-based nucleation and ROP pattern co-alignment enhance protoxylem microtubule patterning.Quantitative plant biology · 2025Article
- KATANIN-mediated microtubule severing is required for MTOC organisation and function in Marchantia polymorpha.Development (Cambridge, England) · 2024Article
- Approximate simulation of cortical microtubule models using dynamical graph grammars.Physical biology · 2023Article
- Brassinosteroid signals cooperate with katanin-mediated microtubule severing to control stamen filament elongation.The EMBO journal · 2023Article
- Microtubule nucleation complex behavior is critical for cortical array homogeneityProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Finding a right place to cut: How katanin is targeted to cellular severing sites.Quantitative plant biology · 2022Review
- Micron-scale geometrical features of microtubules as regulators of microtubule organization.eLife · 2021Review
- Long-term single-cell imaging and simulations of microtubules reveal principles behind wall patterning during proto-xylem development.Nature communications · 2021Article
- Shaping the Organ: A Biologist Guide to Quantitative Models of Plant Morphogenesis.Frontiers in plant science · 2021Review
- Cutting, Amplifying, and Aligning Microtubules with Severing Enzymes.Trends in cell biology · 2021Review
- Cytoskeletal organization in isolated plant cells under geometry control.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Complementary Superresolution Visualization of Composite Plant Microtubule Organization and Dynamics.Frontiers in plant science · 2020Article
- The microtubule cytoskeleton acts as a sensor for stress response signaling in plants.Molecular biology reports · 2019Review
- Spastin is a dual-function enzyme that severs microtubules and promotes their regrowth to increase the number and mass of microtubules.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Article
- A computational framework for cortical microtubule dynamics in realistically shaped plant cells.PLoS computational biology · 2018Article
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Plant morphogenesis requires differential and often asymmetric growth. A key role in controlling anisotropic expansion of individual cells is played by the cortical microtubule array. Although highly organized, the array can nevertheless rapidly change in response to internal and external cues. Experiments have identified the microtubule-severing enzyme katanin as a central player in controlling the organizational state of the array. Katanin action is required both for normal alignment and the adaptation of array orientation to mechanical, environmental, and developmental stimuli. How katanin fulfills its controlling role, however, remains poorly understood. On the one hand, from a theoretical perspective, array ordering depends on the "weeding out" of discordant microtubules through frequent catastrophe-inducing collisions among microtubules. Severing would reduce average microtubule length and lifetime, and consequently weaken the driving force for alignment. On the other hand, it has been suggested that selective severing at microtubule crossovers could facilitate the removal of discordant microtubules. Here we show that this apparent conflict can be resolved by systematically dissecting the role of all of the relevant interactions in silico. This procedure allows the identification of the sufficient and necessary conditions for katanin to promote array alignment, stresses the critical importance of the experimentally observed selective severing of the "crossing" microtubule at crossovers, and reveals a hitherto not appreciated role for microtubule bundling. We show how understanding the underlying mechanism can aid with interpreting experimental results and designing future experiments.
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